ChemicalBook > CAS DataBase List > 6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE

6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE

Product Name
6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE
CAS No.
167158-70-5
Chemical Name
6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE
Synonyms
6-Bromo-2-chloroquinazolin-4-ol;6-Bromo-2-chloroquinazolin-4(3H);2-Chloro-6-broMoquinazolin-4(3H)-one;6-Bromo-2-chloro-4(3H)-quinazolinone;6-bromo-2-chloroquinazolin-4(3H)-one;6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE;4(3H)-Quinazolinone, 6-bromo-2-chloro-;6-bromo-2-chloro-3,4-dihydroquinazolin-4-one
CBNumber
CB62455912
Molecular Formula
C8H4BrClN2O
Formula Weight
259.49
MOL File
167158-70-5.mol
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6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE Property

Boiling point:
393.2±44.0 °C(Predicted)
Density 
1.95
storage temp. 
2-8°C, stored under nitrogen, away from moisture
pka
-3.76±0.20(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C8H4BrClN2O/c9-4-1-2-6-5(3-4)7(13)12-8(10)11-6/h1-3H,(H,11,12,13)
InChIKey
WZVAPPYRAGWFKW-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(Br)C=C2)C(=O)NC=1Cl
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
8514AA
Product name
6-Bromo-2-chloroquinazolin-4(3H)-one
Packaging
100mg
Price
$328
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0367714
Product name
6-BROMO-2-CHLOROQUINAZOLIN-4(3H)-ONE
Purity
95.00%
Packaging
5MG
Price
$496.46
Updated
2021/12/16
AK Scientific
Product number
8514AA
Product name
6-Bromo-2-chloroquinazolin-4(3H)-one
Packaging
500mg
Price
$675
Updated
2021/12/16
Alichem
Product number
167158705
Product name
6-Bromo-2-chloroquinazolin-4(3H)-one
Packaging
5g
Price
$707.02
Updated
2021/12/16
Alichem
Product number
167158705
Product name
6-Bromo-2-chloroquinazolin-4(3H)-one
Packaging
10g
Price
$990
Updated
2021/12/16
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6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE Chemical Properties,Usage,Production

Synthesis

102393-82-8

167158-70-5

Step C: Synthesis of 6-bromo-2-chloroquinazolin-4(3H)-one 6-Bromo-2,4-dichloroquinazoline (2.0 g, 7.20 mmol) was dissolved in THF (17.99 mL), 1N NaOH solution (17.99 mL, 17.99 mmol) was added, and the reaction was stirred for 2.5 h at room temperature. Upon completion of the reaction, the reaction solution was cooled to 0 °C and the pH was adjusted with AcOH to 5. The precipitated light yellow solid was collected by filtration and washed with water. The resulting solid was azeotropized by toluene (3×) to remove residual water to afford 6-bromo-2-chloroquinazolin-4(3H)-one (1.625 g, 87%). The product was analyzed by ES-LCMS: m/z 259.0, 261.0 [M+H]+.

References

[1] Patent: WO2012/87938, 2012, A1. Location in patent: Page/Page column 114
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300

6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE manufacturers

Career Henan Chemical Co
Product
6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE 167158-70-5
Price
US $5.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

167158-70-5, 6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONERelated Search:

6-Bromoquinazolin-4-ol 6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE

  • 6-BROMO-2-CHLOROQUINAZOLIN-4(1H)-ONE
  • 6-bromo-2-chloroquinazolin-4(3H)-one
  • 6-Bromo-2-chloro-4(3H)-quinazolinone
  • 2-Chloro-6-broMoquinazolin-4(3H)-one
  • 6-Bromo-2-chloroquinazolin-4(3H)
  • 4(3H)-Quinazolinone, 6-bromo-2-chloro-
  • 6-Bromo-2-chloroquinazolin-4-ol
  • 6-bromo-2-chloro-3,4-dihydroquinazolin-4-one
  • 167158-70-5
  • 505084-69-3