3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
Uses Application- Product Name
- 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
- CAS No.
- 777931-67-6
- Chemical Name
- 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
- Synonyms
- EOS-61428;2-Chloro-3-bromo-6-methoxypyridine;Pyridine, 3-bromo-2-chloro-6-methoxy-
- CBNumber
- CB62457956
- Molecular Formula
- C6H5BrClNO
- Formula Weight
- 222.47
- MOL File
- 777931-67-6.mol
3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Property
- Boiling point:
- 243.8±35.0 °C(Predicted)
- Density
- 1.650±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.37±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B690368
- Product name
- 3-Bromo-2-chloro-6-methoxypyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B690368
- Product name
- 3-Bromo-2-chloro-6-methoxypyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 150273
- Product name
- 3-Bromo-2-chloro-6-methoxypyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $985
- Updated
- 2021/12/16
- Product number
- HCH0364407
- Product name
- 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.27
- Updated
- 2021/12/16
- Product number
- V7738
- Product name
- 3-Bromo-2-chloro-6-methoxypyridine
- Packaging
- 10g
- Price
- $584
- Updated
- 2021/12/16
3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Chemical Properties,Usage,Production
Uses
2-Chloro-6-methoxy-3-bromopyridine can be used as a pharmaceutical synthesis intermediate.
Application
2-Chloro-6-methoxy-3-bromopyridine can be used as a pharmaceutical synthesis intermediate, such as in the preparation of 2-(6-(1-ethyl-4-fluoro-1H-indazol-6-yl)-2-methoxypyridin-3-yl)-3-methylbutanal: In a 100 mL vial maintained under an inert nitrogen atmosphere, 2-chloro-6-methoxy-3-bromopyridine (2.00 g, 8.900 mmol, 1.00 equivalent) was added, along with Pd(dppf)Cl2.CH2Cl2 (0.36 g, 0.450 mmol, 0.05 equivalent) and Zn(CH3)2 (17 mL, 17.000 mmol, 2.00 equivalent) were added to a solution in 20 mL of 1,4-dioxane. The resulting solution was stirred at 90 °C for 16 h. The mixture was then concentrated under vacuum. The residue was purified by silica gel chromatography and further purified with ethyl acetate/petroleum ether (2:98) to give 2-(6-(1-ethyl-4-fluoro-1H-indazole-6-yl)-2-methoxypyridin-3-yl)-3-methylbutanal as a yellow oil.
Synthesis
17228-64-7
777931-67-6
General procedure for the synthesis of 2-chloro-3-bromo-6-methoxypyridine from 2-chloro-6-methoxypyridine: To a stirred solution of 2-chloro-6-methoxypyridine (7.00 g, 48.8 mmol) in acetonitrile (25 mL) was added N-bromosuccinimide (NBS, 13.0 g, 73.1 mmol) at room temperature. The reaction mixture was refluxed for 24 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium thiosulfate (Na2S2O3) and extracted with ethyl acetate (EtOAc). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel, hexane-ethyl acetate = 98:2) afforded 2-chloro-3-bromo-6-methoxypyridine (6.83 g, 63% yield) as a colorless solid. The product was characterized by the following data: melting point 64-65 °C; IR spectra (film, cm-1 ): 1584, 1551, 1466, 1408, 1344, 1306, 1256, 1155, 1121, 1022, 1009; 1H-NMR (CDCl3, 500 MHz) δ: 7.72 (d, J = 8.50 Hz, 1H), and 6.58 (d, J = 8.50 Hz, 1H), 3.92 (s, 3H); 13C-NMR (CDCl3, 125 MHz) δ: 162.4, 147.3, 143.8, 110.9, 110.1, 54.3; High-resolution mass spectrometry (ESI-TOF): the calculated value C6H6BrClNO [(M + H)+ ] was 221.9316, and the measured value was 221.9314.
References
[1] MedChemComm, 2017, vol. 8, # 4, p. 796 - 806
[2] Organic Letters, 2014, vol. 16, # 7, p. 1980 - 1983
[3] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 7, p. 723 - 732
3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE manufacturers
- Product
- 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE 777931-67-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10T
- Release date
- 2019-12-25