4-CHLORO-2-METHOXY-PYRIDINE
- Product Name
- 4-CHLORO-2-METHOXY-PYRIDINE
- CAS No.
- 72141-44-7
- Chemical Name
- 4-CHLORO-2-METHOXY-PYRIDINE
- Synonyms
- IFLAB-BB F2108-0069;4-chloro-methoxypridine;4-CHLORO-2-METHOXY-PYRIDINE;2-METHOXY-4-CHLORO-PYRIDINE;Pyridine, 4-chloro-2-methoxy-
- CBNumber
- CB0679255
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 72141-44-7.mol
4-CHLORO-2-METHOXY-PYRIDINE Property
- Melting point:
- 26℃
- Boiling point:
- 177℃
- Density
- 1.210
- Flash point:
- 61℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 3.66±0.10(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 72141-44-7(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368675
- Product name
- 4-Chloro-2-methoxypyridine
- Packaging
- 2.5g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 072937
- Product name
- 4-Chloro-2-methoxypyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H56-5-9A
- Product name
- 2-Methoxy-4-chloropyridine
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- FC51062
- Product name
- 4-Chloro-2-methoxy-pyridine
- Packaging
- 10g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 072937
- Product name
- 4-Chloro-2-methoxypyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $253
- Updated
- 2021/12/16
4-CHLORO-2-METHOXY-PYRIDINE Chemical Properties,Usage,Production
Uses
4-Chloro-2-methoxypyridine is a reagent in the preparation of cyclopalladated ferrocenylimines as efficient catalysts for the preparation of arylboronate esters.
Synthesis
98197-72-9
72141-44-7
General procedure for the synthesis of 4-chloro-2-methoxypyridine from 4-iodo-2-methoxypyridine: (d) 50.6 mL of isopropylmagnesium chloride (2 mol/L tetrahydrofuran solution) was mixed with 19.8 g (84.3 mmol) of the crude product of 4-iodo-2-methoxypyridine made in step (c) dissolved in 80 mL of tetrahydrofuran under ice bath cooling conditions. The reaction mixture was stirred at 0 °C for 1 hour, followed by continued stirring at room temperature for 1 hour. Then, 16.9 g (127 mmol) of N-chlorosuccinimide was slowly added and stirring was continued for 1 hour at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of 100 mL of water and the tetrahydrofuran was removed by distillation under reduced pressure. The reaction mixture was extracted with ether and the organic layer was dried with sodium sulfate, filtered and the solvent was removed by decompression distillation to give 11.0 g (91% crude yield) of 4-chloro-2-methoxypyridine crude product. 1H-NMR (CDCl3, 400 MHz): δ (ppm) = 3.91 (s, 3H), 6.70 (d, 1H, J = 2.0 Hz), 6.81 (dd, 1H, J = 6.0 Hz, 2.0 Hz), 7.99 (d, 1H, J = 6.0 Hz).
References
[1] Patent: EP1559320, 2005, A1. Location in patent: Page/Page column 7
4-CHLORO-2-METHOXY-PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-2-METHOXY-PYRIDINE manufacturers
- Product
- 4-CHLORO-2-METHOXY-PYRIDINE 72141-44-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-CHLORO-2-METHOXY-PYRIDINE 72141-44-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24