5-Bromo-2-methoxypyridine
- Product Name
- 5-Bromo-2-methoxypyridine
- CAS No.
- 13472-85-0
- Chemical Name
- 5-Bromo-2-methoxypyridine
- Synonyms
- 5-Bromo-2- Methoxypyidine;2-Methyloxy-5-bromo;5-Bromo-2-methoxypyr;Perampanel Impurity 10;5-BROMO-2-METHOXYPRIDINE;2-METHOXY-5-BROMOPYRIDINE;5-BROMO-2-METHOXYPYRIDINE;5-Bromo-2-methyloxypyridine;PYRIDINE, 5-BROMO-2-METHOXY-;2-Methoxy -5-pyridyl broMide
- CBNumber
- CB7706983
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 13472-85-0.mol
5-Bromo-2-methoxypyridine Property
- Boiling point:
- 80 °C/12 mmHg (lit.)
- Density
- 1.453 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.555(lit.)
- Flash point:
- 205 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 1.04±0.10(Predicted)
- form
- Liquid
- Specific Gravity
- 1.453
- color
- Clear colorless to slightly yellow
- BRN
- 115150
- InChI
- InChI=1S/C6H6BrNO/c1-9-6-3-2-5(7)4-8-6/h2-4H,1H3
- InChIKey
- XADICJHFELMBGX-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=C(Br)C=C1
- LogP
- 0.952
- CAS DataBase Reference
- 13472-85-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
- Storage Class
- 10 - Combustible liquids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 510297
- Product name
- 5-Bromo-2-methoxypyridine
- Purity
- 95%
- Packaging
- 5ml
- Price
- $78.2
- Updated
- 2023/06/20
- Product number
- 510297
- Product name
- 5-Bromo-2-methoxypyridine
- Purity
- 95%
- Packaging
- 25ml
- Price
- $200
- Updated
- 2023/06/20
- Product number
- B2398
- Product name
- 5-Bromo-2-methoxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- B2398
- Product name
- 5-Bromo-2-methoxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- B685095
- Product name
- 5-Bromo-2-methoxypyridine
- Packaging
- 100g
- Price
- $360
- Updated
- 2021/12/16
5-Bromo-2-methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow liquid
Uses
A building block for the β-alanine moiety of an αvβ3 antagonist and for the synthesis of a potent and selective somatostatin sst3 receptor antagonist.
Uses
5-Bromo-2-methoxypyridine is used as a ligand for central nicotinic acetylcholine receptor. Also used in a novel synthetic approach to anti-HIV active integrase inhibitors.
Synthesis
624-28-2
13472-85-0
Step 1. 2,5-dibromopyridine (5.5 g, 23.2 mmol) and sodium methanolate (3.76 g, 69.6 mmol) were dissolved in methanol (60 mL), and the mixture was placed in a sealed reaction vessel and heated to react for 42 hours at 70 °C. After completion of the reaction, the reaction mixture was cooled to room temperature, diluted with water (50 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the light yellow oily product 5-bromo-2-methoxypyridine (4.1 g, 95% yield). Thin layer chromatography (TLC) analytical conditions: 10% ethyl acetate/90% hexane, Rf value of 0.57.
References
[1] Patent: US2002/65296, 2002, A1
[2] Patent: US2004/102636, 2004, A1
[3] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 32-33
[4] Tetrahedron, 1985, vol. 41, # 7, p. 1373 - 1384
[5] Patent: EP1308441, 2003, A1
5-Bromo-2-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-methoxypyridine manufacturers
- Product
- 5-Bromo-2-methoxypyridine 13472-85-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 5-Bromo-2-methoxypyridine 13472-85-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- Perampanel Impurity 10
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-28