ChemicalBook > CAS DataBase List > 5-Bromo-2-methoxypyridine

5-Bromo-2-methoxypyridine

Product Name
5-Bromo-2-methoxypyridine
CAS No.
13472-85-0
Chemical Name
5-Bromo-2-methoxypyridine
Synonyms
5-Bromo-2- Methoxypyidine;2-Methyloxy-5-bromo;5-Bromo-2-methoxypyr;Perampanel Impurity 10;5-BROMO-2-METHOXYPRIDINE;2-METHOXY-5-BROMOPYRIDINE;5-BROMO-2-METHOXYPYRIDINE;5-Bromo-2-methyloxypyridine;PYRIDINE, 5-BROMO-2-METHOXY-;2-Methoxy -5-pyridyl broMide
CBNumber
CB7706983
Molecular Formula
C6H6BrNO
Formula Weight
188.02
MOL File
13472-85-0.mol
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5-Bromo-2-methoxypyridine Property

Boiling point:
80 °C/12 mmHg (lit.)
Density 
1.453 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.555(lit.)
Flash point:
205 °F
storage temp. 
Inert atmosphere,Room Temperature
pka
1.04±0.10(Predicted)
form 
Liquid
Specific Gravity
1.453
color 
Clear colorless to slightly yellow
BRN 
115150
InChI
InChI=1S/C6H6BrNO/c1-9-6-3-2-5(7)4-8-6/h2-4H,1H3
InChIKey
XADICJHFELMBGX-UHFFFAOYSA-N
SMILES
C1(OC)=NC=C(Br)C=C1
LogP
0.952
CAS DataBase Reference
13472-85-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
510297
Product name
5-Bromo-2-methoxypyridine
Purity
95%
Packaging
5ml
Price
$78.2
Updated
2023/06/20
Sigma-Aldrich
Product number
510297
Product name
5-Bromo-2-methoxypyridine
Purity
95%
Packaging
25ml
Price
$200
Updated
2023/06/20
TCI Chemical
Product number
B2398
Product name
5-Bromo-2-methoxypyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
B2398
Product name
5-Bromo-2-methoxypyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$84
Updated
2025/07/31
TRC
Product number
B685095
Product name
5-Bromo-2-methoxypyridine
Packaging
100g
Price
$360
Updated
2021/12/16
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5-Bromo-2-methoxypyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

A building block for the β-alanine moiety of an αvβ3 antagonist and for the synthesis of a potent and selective somatostatin sst3 receptor antagonist.

Uses

5-Bromo-2-methoxypyridine is used as a ligand for central nicotinic acetylcholine receptor. Also used in a novel synthetic approach to anti-HIV active integrase inhibitors.

Synthesis

624-28-2

13472-85-0

Step 1. 2,5-dibromopyridine (5.5 g, 23.2 mmol) and sodium methanolate (3.76 g, 69.6 mmol) were dissolved in methanol (60 mL), and the mixture was placed in a sealed reaction vessel and heated to react for 42 hours at 70 °C. After completion of the reaction, the reaction mixture was cooled to room temperature, diluted with water (50 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the light yellow oily product 5-bromo-2-methoxypyridine (4.1 g, 95% yield). Thin layer chromatography (TLC) analytical conditions: 10% ethyl acetate/90% hexane, Rf value of 0.57.

References

[1] Patent: US2002/65296, 2002, A1
[2] Patent: US2004/102636, 2004, A1
[3] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 32-33
[4] Tetrahedron, 1985, vol. 41, # 7, p. 1373 - 1384
[5] Patent: EP1308441, 2003, A1

5-Bromo-2-methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Methoxy-5-pyridineboronic acid 6-Methoxynicotinaldehyde 2-HYDROXY-5-FORMYLPYRIDINE 5-BROMO-3-CHLORO-2-PYRIDINONE 5-BROMO-3-FLUORO-2-PYRIDINONE
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5-Bromo-2-methoxypyridine Suppliers

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View Lastest Price from 5-Bromo-2-methoxypyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Bromo-2-methoxypyridine 13472-85-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Aochuang Chemical Co.,Ltd.
Product
5-Bromo-2-methoxypyridine 13472-85-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Perampanel Impurity 10
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-28

13472-85-0, 5-Bromo-2-methoxypyridineRelated Search:

5-Bromo-2-methoxy-6-picoline 4-Methoxyphenol 2-Methoxypyridine p-Anisaldehyde 1-Hexadecylpyridinium bromide 2-Chloro-5-chloromethylpyridine Guaiacol p-Anisidine 2,5-Dimethylpyridine (Trifluoromethoxy)benzene Anisole 5-Bromo-2-hydroxymethylpyridine 5-Bromo-2-methylpyridine 5-BROMO-2-(METHYLTHIO)PYRIMIDINE 2-PHENYL-1,3,2-DIOXABORINANE PeraMpanel 2-bromo-3-(1,3,2-dioxaborinan-2-yl)benzonitrile 6'-Methoxy-2,3'-bipyridine

  • 2-METHOXY-5-BROMOPYRIDINE 5-BROMO-2-METHOXY-PYRIDINE
  • 5-Bromo-2-methoxypyridine 95%
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  • 2-Methoxy -5-pyridyl broMide
  • 2 - Methoxy - 5 - broMide pyridine
  • 5-2 - Methoxy pyridine broMide -
  • PYRIDINE, 5-BROMO-2-METHOXY-
  • 2-METHOXY-5-BROMOPYRIDINE
  • 5-BROMO-2-METHOXYPYRIDINE
  • 5-BROMO-2-METHOXYPRIDINE
  • 5-Bromo-2-methoxypyridine &gt
  • Perampanel Impurity 10
  • 5-Bromo-2-methoxypyridine ISO 9001：2015 REACH
  • 5-Bromo-2-methyloxypyridine
  • "5 - bromine - 2 - a Oxygen radicals pyridine (pyrazole shimron Nai impurities A - 2)"
  • 5-Bromo-2- Methoxypyidine
  • 2-Methyloxy-5-bromo
  • 13472-85-0
  • Bromopyridines
  • Halopyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • alkyl bromide
  • Brominated heterocyclic series
  • Halopyridines
  • Boronic Acid
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • compounds of pyridine
  • Alkoxy
  • Organohalides
  • Pyridines derivates
  • Pyridine Series
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Bromine Compounds
  • Miscellaneous Compounds
  • Bromopyridines
  • blocks
  • Bromides
  • Pyridines
  • Pyridine
  • pyridine derivative