2-Methoxy-5-pyridineboronic acid
- Product Name
- 2-Methoxy-5-pyridineboronic acid
- CAS No.
- 163105-89-3
- Chemical Name
- 2-Methoxy-5-pyridineboronic acid
- Synonyms
- (6-METHOXYPYRIDIN-3-YL)BORONIC ACID;2-METHOXYPYRIDINE-5-BORONIC ACID;Sudan 455;AKOS BRN-0148;CAS:163105-89-3;2-Methoxy-5-pyridine;Perampanel Impurity ZY1;2-Methoxy-5-pyridine acid;2-Methoxy-5-pyridinylboronic;2-Methoxy-5-pyridineboronicaci
- CBNumber
- CB2241607
- Molecular Formula
- C6H8BNO3
- Formula Weight
- 152.94
- MOL File
- 163105-89-3.mol
2-Methoxy-5-pyridineboronic acid Property
- Melting point:
- 135-140 °C(lit.)
- Boiling point:
- 313.2±52.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 7.26±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- Soluble in water.
- BRN
- 9119950
- InChIKey
- DHADXDMPEUWEAS-UHFFFAOYSA-N
- CAS DataBase Reference
- 163105-89-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 22-24/25-36/37/39-26-23
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, AIR SENSITIVE, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 637610
- Product name
- 6-Methoxy-3-pyridinylboronic acid
- Purity
- ≥95.0%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- 637610
- Product name
- 6-Methoxy-3-pyridinylboronic acid
- Purity
- ≥95.0%
- Packaging
- 5g
- Price
- $71.1
- Updated
- 2023/06/20
- Product number
- M2029
- Product name
- 2-Methoxypyridine-5-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- M2029
- Product name
- 2-Methoxypyridine-5-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- 281705
- Product name
- 6-Methoxypyridin-3-ylboronic acid
- Packaging
- 2g
- Price
- $352
- Updated
- 2021/12/16
2-Methoxy-5-pyridineboronic acid Chemical Properties,Usage,Production
Chemical Properties
White to beige powder
Uses
2-Methoxypyridine-5-boronic acid is used in cosmetics, coatings candles.
Synthesis
13472-85-0
163105-89-3
General procedure for the synthesis of (6-methoxypyridin-3-yl)boronic acid from 5-bromo-2-methoxypyridine: To a stirred solution of 17.0 mL (0.131 mol) of 5-bromo-2-methoxypyridine dissolved in 130 mL of THF at -78 °C, 79 mL (0.197 mol) of 2.5 M n-butyllithium (dissolved in hexanes) was slowly added. The temperature was maintained at -78 °C and stirring was continued for 2 min. Subsequently, 45 mL (0.197 mol) of triisopropoxyborane [B(OiPr)3] was added to the reaction system and the reaction mixture was allowed to slowly warm up to room temperature over 12 hours. Upon completion of the reaction, the mixture was poured into 300 mL of a 1.0 N aqueous hydrochloric acid solution and stirred vigorously for 30 minutes. The pH of the mixture was adjusted to 7.0 with 3.0 N aqueous sodium hydroxide solution and subsequently extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed with 200 mL of brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in 350 mL of 2.0 M aqueous sodium hydroxide and washed with ethyl acetate (2 x 200 mL). The aqueous phase was adjusted to pH 7.0 with concentrated hydrochloric acid to precipitate a solid. The solid was collected by filtration, washed with water and dried to give 15.01 g (75% yield) of [6-(methoxy)-3-pyridinyl]boronic acid as a white powder. Its 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 8.51 (s, 1H), 8.12 (bs, 2H), 7.95 (d, 1H, J = 7.8 Hz), 6.73 (d, 1H, J = 7.8 Hz), 3.83 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 1, p. 224 - 239
[2] Patent: WO2008/28118, 2008, A1. Location in patent: Page/Page column 77
[3] Journal of Organic Chemistry, 2005, vol. 70, # 1, p. 388 - 390
[4] Journal of Organic Chemistry, 2002, vol. 67, # 21, p. 7541 - 7543
[5] Patent: US2006/111394, 2006, A1. Location in patent: Page/Page column 17
2-Methoxy-5-pyridineboronic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Methoxy-5-pyridineboronic acid manufacturers
- Product
- 2-Methoxy-5-pyridineboronic acid 163105-89-3
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-09
- Product
- 2-Methoxy-5-pyridineboronic acid 163105-89-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- 2-Methoxy-5-pyridineboronic acid 163105-89-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13