5-Amino-2-methoxypyridine
- Product Name
- 5-Amino-2-methoxypyridine
- CAS No.
- 6628-77-9
- Chemical Name
- 5-Amino-2-methoxypyridine
- Synonyms
- 6-METHOXYPYRIDIN-3-AMINE;5-Amino-2-methoxy;3-Amino-6-methoxypy;OTAVA-BB BB7020410079;6-methoxy-3-pyridinamin;6-methoxypyridin-3-amin;6-Methoxy-3-pyridylamine;6-Methoxy-3-pyridinamine;2-Methoxypyridin-5-amine;5-amino-2-methoxy-pyridin
- CBNumber
- CB9280737
- Molecular Formula
- C6H8N2O
- Formula Weight
- 124.14
- MOL File
- 6628-77-9.mol
5-Amino-2-methoxypyridine Property
- Melting point:
- 29-31 °C (lit.)
- Boiling point:
- 85-90 °C/1 mmHg (lit.)
- Density
- 1.575
- refractive index
- n20/D 1.575(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Liquid
- pka
- 4.33±0.10(Predicted)
- color
- Yellow-brown or red to very dark red
- Water Solubility
- Slightly soluble
- CAS DataBase Reference
- 6628-77-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Amino-2-methoxypyridine(6628-77-9)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- RTECS
- US1836000
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A61209
- Product name
- 5-Amino-2-methoxypyridine
- Purity
- 95%
- Packaging
- 25g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- A61209
- Product name
- 5-Amino-2-methoxypyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $55.1
- Updated
- 2023/06/20
- Product number
- A1956
- Product name
- 5-Amino-2-methoxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- A1956
- Product name
- 5-Amino-2-methoxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- A612185
- Product name
- 5-Amino-2-methoxypyridine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
5-Amino-2-methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
yellow-brown or red to very dark red liquid
Uses
5-Amino-2-methoxypyridine is used as a reagent in the synthesis of a novel series of thienopyrimidines as highly potent and selective PI3K inhibitors. 5-Amino-2-methoxypyridine is also used to synthesize EMPA (E521550); a novel high-affinity selective antagonist for the OX2 receptor.
Definition
ChEBI: 6-Methoxypyridin-3-amine is an aminopyridine.
Synthesis
5446-92-4
6628-77-9
The general procedure for the synthesis of 5-amino-2-methoxypyridine from 5-nitro-2-methoxypyridine was as follows: 67.28 g of 2-methoxy-5-nitropyridine (0.1 mol), 0.50 g of 10% Pd/C were sequentially added to methanol, hydrogen was passed to a pressure of 0.01 MPa, and the reaction was carried out for 62±1.5 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and filtered to recover the 10% Pd/C catalyst. The filtrate was concentrated under reduced pressure to recover solvent. The residue was extracted twice with 75 g of dichloroethane and the combined extracts were washed once with purified water. Subsequently, the extract was evaporated under reduced pressure to afford a slightly yellow oily liquid 5-amino-2-methoxypyridine 11.69 g. The purity was determined by HPLC to be 97.63% and the yield was 92.03%.
References
[1] Synthesis, 2006, # 19, p. 3316 - 3340
[2] Tetrahedron Letters, 2010, vol. 51, # 5, p. 786 - 789
[3] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 302 - 318
[4] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 302 - 318
[5] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 199 - 203
5-Amino-2-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Amino-2-methoxypyridine manufacturers
- Product
- 5-Amino-2-methoxypyridine 6628-77-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 5-Amino-2-methoxypyridine 6628-77-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 5-Amino-2-methoxypyridine 6628-77-9
- Price
- US $10.50/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21