2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER
- Product Name
- 2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER
- CAS No.
- 863578-21-6
- Chemical Name
- 2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER
- Synonyms
- 25G 100G 500G;2-Amino-4-chlorophenyl boronic acid;2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER;5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);5-chloro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline;Benzenamine, 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber
- CB62459763
- Molecular Formula
- C12H17BClNO2
- Formula Weight
- 253.53
- MOL File
- 863578-21-6.mol
2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER Property
- Boiling point:
- 363.6±32.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 2.84±0.11(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A617568
- Product name
- 2-Amino-4-chlorophenylboronicacidpinacolester
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A617568
- Product name
- 2-Amino-4-chlorophenylboronicacidpinacolester
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA160776
- Product name
- 2-Amino-4-chlorophenylboronic acid pinacol ester
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FA160776
- Product name
- 2-Amino-4-chlorophenylboronic acid pinacol ester
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FA160776
- Product name
- 2-Amino-4-chlorophenylboronic acid pinacol ester
- Packaging
- 500mg
- Price
- $325
- Updated
- 2021/12/16
2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production
Synthesis
823-57-4
25015-63-8
863578-21-6
Step 1: Preparation of 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline To a solution of 2-bromo-5-chloroaniline (20.0 g, 96.9 mmol) in 1,4-dioxane (200 ml) was sequentially added triethylamine (54.0 ml, 487 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane complex (3.96 g, 4.84 mmol) under nitrogen protection. Subsequently, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (42.3 ml, 290 mmol) was slowly added dropwise. The reaction mixture was stirred at 100 °C for 10.5 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth. The filtrate was quenched by dropwise addition of methanol (25 ml) at 0°C. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 20:1) to afford the target product 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (16.5 g, 65% yield). 1H-NMR (400 MHz, DMSO-d6): δ (ppm) 7.28 (1H, d, J=6.0 Hz), 6.59 (1H, d, J=1.2 Hz), 6.43 (1H, dd, J=6.3,1.5 Hz), 5.70 (2H, s), 1.24 (12H, s).
References
[1] Patent: EP1719773, 2006, A1. Location in patent: Example 1-10
2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER manufacturers
- Product
- 2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER 863578-21-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-21
- Product
- 2-AMINO-4-CHLOROPHENYL BORONIC ACID PINACOL ESTER 863578-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12