Ethyl 4,6-dichloropyrridazine-3-carboxylate

Product Name: Ethyl 4,6-dichloropyrridazine-3-carboxylate
CAS No.: 679406-03-2
Chemical Name: Ethyl 4,6-dichloropyrridazine-3-carboxylate
Synonyms: 4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester;EOS-61510;4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE;ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE;Ethyl 4,6-dichloro-3-pyridazinecarboxylate;Ethyl 4,6-dichloropyrridazine-3-carboxylate;4,6-Dichloropyrazine-3-carboxylic acid ethyl ester;3-Pyridazinecarboxylic acid, 4,6-dichloro-, ethyl ester
CBNumber: CB62461124
Molecular Formula: C7H6Cl2N2O2
Formula Weight: 221.04
MOL File: 679406-03-2.mol

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Ethyl 4,6-dichloropyrridazine-3-carboxylate Property

Boiling point:: 353.4±37.0 °C(Predicted)
Density: 1.433±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Acetonitrile (Slightly), Chloroform (Soluble), Methanol (Slightly)
pka: -2.18±0.10(Predicted)
form: Low-Melting Solid
color: Brown to Very Dark Brown
InChI: InChI=1S/C7H6Cl2N2O2/c1-2-13-7(12)6-4(8)3-5(9)10-11-6/h3H,2H2,1H3
InChIKey: MOWPWJUYSRHMHS-UHFFFAOYSA-N
SMILES: C1(C(OCC)=O)=NN=C(Cl)C=C1Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E903353
Product name: ethyl4,6-dichloropyridazine-3-carboxylate
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W022681
Product name: Ethyl4,6-dichloropyridazine-3-carboxylate
Purity: 97.15%
Packaging: 1g
Price: $96
Updated: 2021/12/16

AK Scientific

Product number: W7825
Product name: Ethyl4,6-dichloropyridazine-3-carboxylate
Packaging: 1g
Price: $262
Updated: 2021/12/16

ChemScene

Product number: CS-W022681
Product name: Ethyl4,6-dichloropyridazine-3-carboxylate
Purity: 97.15%
Packaging: 5g
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-W022681
Product name: Ethyl4,6-dichloropyridazine-3-carboxylate
Purity: 97.15%
Packaging: 10g
Price: $450
Updated: 2021/12/16

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Ethyl 4,6-dichloropyrridazine-3-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 4,6-Dichloropyridazine-3-carboxylate is a useful reagent for the green preparation of Deucravacitinib, a deuterated API for TYK2 Inhibition.

Synthesis

To a 350 mL nitrogen purged Schlenk flask containing Ethyl 4,6-dihydroxypyridazine-3-carboxylate (3.77 g, 20.47 mmol) was added phosphorus oxychloride (38 mL, 408 mmol). The vessel was sealed and heated to 100 °C for 3.5 hours. The reaction was cooled to room temperature and the excess phosphorus oxychloride was removed in vacuo. The crude oil was dissolved into chloroform, re-concentrated and then poured into ice water, rinsing with ethyl acetate.The two layers were transferred to a separatory funnel, separated and the aqueous layer extracted 3x with ethyl acetate. The combined organic layers were washed twice with water and once with brine (saturated aqueous sodium chloride) and then dried over sodium sulfate, filtered, concentrated and then purified by automated chromatography (5- 90percent EtOAc:hexanes), providing Ethyl 4,6-dichloropyrridazine-3-carboxylate (3.64 g, 16.3 mmol). ‘H NMR (400MHz, chloroform-d) ? 7.70 (s, 1H), 4.55 (qd, J=7.1, 1.1 Hz, 2H), 1.46 (td, J=7.2, 0.9 Hz, 3H).

References

[1] Patent: WO2014/74661, 2014, A1. Location in patent: Paragraph 00162
[2] Patent: WO2015/123453, 2015, A1. Location in patent: Paragraph 0177
[3] Patent: US2004/77653, 2004, A1. Location in patent: Page 18
[4] Patent: WO2018/183649, 2018, A1. Location in patent: Page/Page column 18

Ethyl 4,6-dichloropyrridazine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4,6-dichloropyrridazine-3-carboxylate Suppliers

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View Lastest Price from Ethyl 4,6-dichloropyrridazine-3-carboxylate manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: Ethyl 4,6-dichloropyridazine-3-carboxylate 679406-03-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-29

Hangzhou ICH Biofarm Co., Ltd

Product: Ethyl 4,6-dichloropyrridazine-3-carboxylate 679406-03-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 20 tons
Release date: 2023-07-03

Jiangsu Guotai Guomian Trading Co. Ltd.

Product: Ethyl 4,6-dichloropyrridazine-3-carboxylate 679406-03-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: In house standard.
Supply Ability: 1 ton
Release date: 2023-02-06

679406-03-2, Ethyl 4,6-dichloropyrridazine-3-carboxylateRelated Search:

Methyl 4,6-dichloropyridazine-3-carboxylate

4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester

ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE

EOS-61510

4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE

3-Pyridazinecarboxylic acid, 4,6-dichloro-, ethyl ester

Ethyl 4,6-dichloropyrridazine-3-carboxylate

4,6-Dichloropyrazine-3-carboxylic acid ethyl ester

Ethyl 4,6-dichloro-3-pyridazinecarboxylate

679406-03-2