Methyl 4,6-dichloropyridazine-3-carboxylate
- Product Name
- Methyl 4,6-dichloropyridazine-3-carboxylate
- CAS No.
- 372118-01-9
- Chemical Name
- Methyl 4,6-dichloropyridazine-3-carboxylate
- Synonyms
- Deucravacitinib intermediate;3-Methoxycarbonyl-4,6-dichloropyridazine;4,6-Dichloro-4-(methoxycarbonyl)pyridazine;METHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLAT;Methyl 4,6-dichloro-3-pyridazinecarboxylate;METHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE;4,6-dichloropyridazine-3-carboxylate Methyl;Methyl4,6-dichloropyridazine-3-carboxylate,97%;6-dichloro-pyridazine-3-carboxylic acid methyl ester;4,6-dichloropyridazin-3-carboxylic acid methyl ester
- CBNumber
- CB32453265
- Molecular Formula
- C6H4Cl2N2O2
- Formula Weight
- 207.01
- MOL File
- 372118-01-9.mol
Methyl 4,6-dichloropyridazine-3-carboxylate Property
- Boiling point:
- 345.2±37.0 °C(Predicted)
- Density
- 1.503±0.06 g/cm3(Predicted)
- refractive index
- 1.552
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- pka
- -2.30±0.10(Predicted)
- form
- powder
- color
- Light beige/light brown crystalline
- InChI
- InChI=1S/C6H4Cl2N2O2/c1-12-6(11)5-3(7)2-4(8)9-10-5/h2H,1H3
- InChIKey
- MZEVRGMQXLNKEZ-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NN=C(Cl)C=C1Cl
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M301403
- Product name
- Methyl4,6-dichloropyridazine-3-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR20002
- Product name
- Methyl4,6-dichloropyridazine-3-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 4H23-5-70
- Product name
- Methyl 4,6-dichloropyridazine-3-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $71
- Updated
- 2021/12/16
- Product number
- W5824
- Product name
- Methyl4,6-dichloropyridazine-3-carboxylate
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 074212
- Product name
- Methyl 4,6-dichloropyridazine-3-carboxylate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
Methyl 4,6-dichloropyridazine-3-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 4,6-dichloropyridazine-3-carboxylate is an organic intermediate commonly used in laboratory research and development as a raw material for organic synthesis.
Synthesis
372118-00-8
372118-01-9
Step 3 Synthesis of methyl 4,6-dichloropyridazine-3-carboxylate: 4,6-dihydroxypyridazine-3-carboxylic acid methyl ester (10.5 g, 61.7 mmol) was mixed with phosphorous trichloride (70 mL), heated to 95 °C, and the reaction was carried out for 5 hours. After completion of the reaction, the excess phosphorous trichloride was evaporated under reduced pressure. The crude product was slowly poured into ice water (250 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh, 30% ethyl acetate in hexane solution as eluent) to afford methyl 4,6-dichloropyridazine-3-carboxylate (9.2 g, 72% yield) as an off-white solid.LC-MS: 207.0 [M + H]+.
References
[1] Patent: US2013/178478, 2013, A1. Location in patent: Paragraph 0301;0302
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2683 - 2691
[3] Patent: US2004/77653, 2004, A1. Location in patent: Page 18
Methyl 4,6-dichloropyridazine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4,6-dichloropyridazine-3-carboxylate manufacturers
- Product
- 4,6-Dichloro-pyridazine-3-carboxylic acid Methyl ester 372118-01-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 4,6-Dichloro-4-(methoxycarbonyl)pyridazine 372118-01-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 50 ton
- Release date
- 2024-08-23
- Product
- METHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE 372118-01-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02