Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)
- Product Name
- Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)
- CAS No.
- 191478-99-6
- Chemical Name
- Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)
- Synonyms
- 4-Amino-2,6-difluorobenzoate methyl;Methyl 4-amino-2,6-difluorobenzoate;4-Amino-2,6-difuluorobenzoic methyl ester;4-Amino-2,6-difluorobenzoic acid methyl ester;Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI);Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) USP/EP/BP
- CBNumber
- CB71054698
- Molecular Formula
- C8H7F2NO2
- Formula Weight
- 187.14
- MOL File
- 191478-99-6.mol
Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Property
- Boiling point:
- 306℃
- Density
- 1.355
- Flash point:
- 139℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 0.44±0.10(Predicted)
- Appearance
- Gray to brown Solid
Safety
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M878198
- Product name
- Methyl4-amino-2,6-difluorobenzoate
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- HCH0369380
- Product name
- METHYL-4-AMINO-2,6-DIFLUOROBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.35
- Updated
- 2021/12/16
- Product number
- 9950AA
- Product name
- Methyl4-amino-2,6-difluorobenzoate
- Packaging
- 10g
- Price
- $871
- Updated
- 2021/12/16
- Product number
- CM128262
- Product name
- methyl4-amino-2,6-difluorobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $271
- Updated
- 2021/12/16
- Product number
- CD12101085
- Product name
- Methyl4-amino-2,6-difluorobenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $287
- Updated
- 2021/12/16
Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Chemical Properties,Usage,Production
Uses
Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) can be used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs.
Synthesis
129589-63-5
191478-99-6
Methyl 4-[(tert-butoxycarbonyl)amino]-2,6-difluorobenzoate (36 mg, 0.125 mmol) was used as a starting material and 0.5 mL of trifluoroacetic acid (TFA) was added to its solution in 1 mL of dichloromethane at room temperature. The reaction mixture was stirred for 30 minutes at room temperature. Subsequently, the reaction solution was concentrated under reduced pressure and the residue was co-evaporated with dichloromethane and toluene several times to completely remove the residual trifluoroacetic acid. Finally, the product was dried under reduced pressure. The resulting crude product, methyl 4-amino-2,6-difluorobenzoate (24 mg, quantitative yield), could be used in subsequent reactions without further purification.
References
[1] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 0677-0680
[2] Patent: KR2015/137095, 2015, A. Location in patent: Paragraph 0902-0905
Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) manufacturers
- Product
- Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) 191478-99-6
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-09