6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 878207-92-2
- Chemical Name
- 6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- methyl 6-chloro-3-methylpicolinate;methyl 6-chloro-3-methylpyridine-2-carboxylate;6-Chloro-3-methyl-2-pyridinecarboxylic acid methyl ester;6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;Methyl 6-chloro-3-methylpicolinate, 6-Chloro-2-(methoxycar;2-Pyridinecarboxylic acid, 6-chloro-3-methyl-, methyl ester;Methyl 6-chloro-3-methylpicolinate, 6-Chloro-2-(methoxycarbonyl)-3-methylpyridine
- CBNumber
- CB41013108
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- 878207-92-2.mol
6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Property
- Boiling point:
- 288.7±35.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.53±0.10(Predicted)
- form
- wooly crystalline powder
- color
- White
- InChI
- InChI=1S/C8H8ClNO2/c1-5-3-4-6(9)10-7(5)8(11)12-2/h3-4H,1-2H3
- InChIKey
- XWPSWOKQWBNRDW-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(Cl)=CC=C1C
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M342288
- Product name
- Methyl6-chloro-3-methylpicolinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR60156
- Product name
- Methyl6-chloro-3-methylpyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 4H23-5-V5
- Product name
- Methyl 6-chloro-3-methylpyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR60156
- Product name
- Methyl6-chloro-3-methylpyridine-2-carboxylate
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 4H23-5-V5
- Product name
- Methyl 6-chloro-3-methylpyridine-2-carboxylate
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
878207-91-1
878207-92-2
2-(Methoxycarbonyl)-3-methylpyridin-1-en-1-ol salt (500 mg, 2.99 mmol, 1.00 eq.) was used as a starting material and dissolved in phosphoryl chloride (2 mL). The reaction mixture was stirred at 110 °C for 4 hours. Upon completion of the reaction, the reaction was quenched with ice water and the pH was adjusted to 7. Subsequently, the aqueous phase was extracted with ethyl acetate (3 × 10 mL). The organic layers were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:5, v/v) as eluent to afford methyl 6-chloro-3-methylpyridine-2-carboxylate (230 mg, 41% yield) as a white solid.LC-MS (ESI, m/z): 186 [M + H]+.
References
[1] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 1234; 1235
[2] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 268
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 6, p. 1736 - 1739
[4] Patent: WO2014/209727, 2014, A1. Location in patent: Page/Page column 69
[5] Patent: WO2014/205593, 2014, A1. Location in patent: Page/Page column 73
6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 6-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 878207-92-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26