ChemicalBook > CAS DataBase List > 7-Ethyl-10-hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin
- Product Name
- 7-Ethyl-10-hydroxycamptothecin
- CAS No.
- 130144-34-2
- Chemical Name
- 7-Ethyl-10-hydroxycamptothecin
- Synonyms
- Camptothecin Impurity 21;7-Ethyl-10-hydroxycamptothecin;7-ETHYL-10-HYDROXYCAMPTOTHECIN;7-Ethyl-10-hydroxycamptothecin;(rac)-7-Ethyl-10-Hydroxy camptothecin;rac-4,11-Diethyl-9-hydroxycamptothecin;7-Ethyl-10-hydroxycamptothecin, racemic;(110714-48-2) 7-ethyl-10-hydroxycamptothecin;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-
- CBNumber
- CB62462141
- Molecular Formula
- C22H20N2O5
- Formula Weight
- 392.41
- MOL File
- 130144-34-2.mol
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7-Ethyl-10-hydroxycamptothecin Property
- Boiling point:
- 810.3±65.0 °C(Predicted)
- Density
- 1.51
- pka
- 9.13±0.40(Predicted)
- InChI
- InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3
- InChIKey
- FJHBVJOVLFPMQE-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O
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7-Ethyl-10-hydroxycamptothecin Chemical Properties,Usage,Production
Description
7-Ethyl-10-hydroxycamptothecin: a potent topoisomerase I inhibitor
7-Ethyl-10-hydroxycamptothecin (SN-38), as a highly active topoisomerase (Topo) I inhibitor, is the active metabolic product of its prodrug irinotecan (CPT-11) commercially available as Camptosar. By combining with the Topo I-DNA covalent conjugate, the camptothecin analogue forms a ternary complex that blocks the repolymerization of the DNA strands during their replication, eventually leading to the cell apoptosis. Although SN-38 is about 100- to 1000-fold more potent than irinotecan, its clinical application is limited by its poor solubility and nonspecific toxicity[1].
Definition
ChEBI: LSM-6189 is a pyranoindolizinoquinoline.
References
[1] Shuangxi Liu. “Co-Prodrugs of 7-Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects.” ACS Omega 5 1 (2019): 350–357.
7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Ethyl-10-hydroxycamptothecin manufacturers
Career Henan Chemical Co
- Product
- 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 130144-34-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-28