ChemicalBook > CAS DataBase List > 4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco

4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco

Product Name
4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco
CAS No.
859169-20-3
Chemical Name
4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco
Synonyms
4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco;Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-;Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);(4-(2-ETHOXY-2-OXOETHYL)PHENYL)BORONIC ACID PINACOL ESTER;Ethyl 2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate;4-(4-(Ethoxycarbonyl)phenyl)benzeneboronic acid neopentyl glycol ester;2-[(4-Ethoxycarbonylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Ethyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Acetate,>98%;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzeneacetic acid ethyl ester;ETHYL 2-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)ACETATE（WS202804）
CBNumber
CB62462222
Molecular Formula
C16H23BO4
Formula Weight
290.16
MOL File
859169-20-3.mol
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4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco Property

Boiling point:
377.7±25.0 °C(Predicted)
Density 
1.06±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
color 
Colorless to Light yellow to Light orange
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BML00213
Product name
4-(Ethoxycarbonylmethyl)phenylboronic acid pinacol ester
Purity
Aldrich
Packaging
1g
Price
$286
Updated
2025/07/31
TCI Chemical
Product number
E1393
Product name
Ethyl 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate
Packaging
1G
Price
$149
Updated
2025/07/31
TRC
Product number
E895008
Product name
4-(Ethoxycarbonylmethyl)phenylboronic acid pinacol ester
Packaging
1g
Price
$180
Updated
2021/12/16
SynQuest Laboratories
Product number
6660-1-PB
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzeneacetic acid ethyl ester
Packaging
1g
Price
$183
Updated
2021/12/16
Matrix Scientific
Product number
074434
Product name
(4-Ethoxycarbonylmethylphenyl)-boronic acid pinacol ester
Purity
95+%
Packaging
5g
Price
$166
Updated
2021/12/16
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4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco Chemical Properties,Usage,Production

Uses

4-Ethoxycarbonylmethylphenylboronic acid, pinacol ester

Synthesis

14062-25-0

73183-34-3

859169-20-3

GENERAL STEPS: Ethyl (4-bromophenyl)acetate (100 g, 411 mmol), bis(pinacolato)diboron (125.4 g, 493.7 mmol), and potassium acetate (125.4 g, 493.7 mmol) were added to a 2L round bottom flask. 1,4-dioxane (1 L) was added and stirred under nitrogen protection for 15 min. Subsequently, [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane complex (3.36 g, 4.11 mmol) was added, and the reaction mixture was heated in an oil bath at 100 °C for 2 hours. The reaction process was monitored by analytical HPLC. After completion of the reaction, 1,4-dioxane was removed by concentration under reduced pressure and the residue was dissolved in ethyl acetate. The solution was filtered through a silica gel column (6 x 4 in.) and ethyl acetate (1.5 L) was used as eluent to afford ethyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate (117 g, 98% yield).1H NMR (400 MHz, DMSO) δ ppm: 7.63 (d, 2H, J=8 Hz). 7.27 (d, 2H, J=8Hz), 4.07 (q, 2H, J=7Hz), 3.68 (s, 2H), 1.28 (s, 12H), 1.16 (t, 3H, J=7Hz).

References

[1] Patent: WO2006/86609, 2006, A2. Location in patent: Page/Page column 152-153
[2] Patent: US2014/206686, 2014, A1. Location in patent: Paragraph 0452-0454
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7920 - 7939,20
[4] Patent: WO2013/189865, 2013, A1. Location in patent: Page/Page column 30
[5] Patent: US2012/295874, 2012, A1. Location in patent: Page/Page column 230

4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco 859169-20-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco 859169-20-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco 859169-20-3
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
1kg; 5kg
Release date
2020-02-03

859169-20-3, 4-(ethoxycarbonylmethyl)phenylboronic acid, pinacoRelated Search:

4-(METHOXYCARBONYL)PHENYLBORONIC ACID 2-(5-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Amino-2-fluorophenylboronic acid, pinacol ester 1-Methylindazole-5-boroni... 4-Nitrophenylboronic acid pinacol ester 3-Fluoro-4-nitrophenylboronic acid,pinacol ester 3-Fluoro-4-methoxyphenylboronic acid, pinacol ester 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester 1H-Indazole, 1-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 4-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester 2-(3,5-Dichloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER

  • 4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco
  • Ethyl 2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
  • Benzeneacetic acid, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester
  • ETHYL 2-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)ACETATE（WS202804）
  • (4-(2-ETHOXY-2-OXOETHYL)PHENYL)BORONIC ACID PINACOL ESTER
  • Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-
  • Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzeneacetic acid ethyl ester
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-benzeneacetic acid ethyl ester 97%
  • Ethyl 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Acetate,>98%
  • 2-[(4-Ethoxycarbonylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic Acid Ethyl Ester
  • 4-(4-(Ethoxycarbonyl)phenyl)benzeneboronic acid neopentyl glycol ester
  • 859169-20-3