ChemicalBook > CAS DataBase List > ISOXAZOLIDINE HYDROCHLORIDE

ISOXAZOLIDINE HYDROCHLORIDE

Product Name: ISOXAZOLIDINE HYDROCHLORIDE
CAS No.: 39657-45-9
Chemical Name: ISOXAZOLIDINE HYDROCHLORIDE
Synonyms: hydrochloride - [K86659];1,2-Oxazolidine hydrochloride;Isoxazolidine, hydrochloride (1:1)
CBNumber: CB62464615
Molecular Formula: C3H7NO.ClH
Formula Weight: 109.555
MOL File: 39657-45-9.mol

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ISOXAZOLIDINE HYDROCHLORIDE Property

Melting point:: 125.0 to 129.0 °C
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Soluble in water
form: powder to crystal
color: White to Almost white

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: I0966
Product name: Isoxazolidine Hydrochloride
Purity: >97.0%(T)
Packaging: 1g
Price: $171
Updated: 2025/07/31

TCI Chemical

Product number: I0966
Product name: Isoxazolidine Hydrochloride
Purity: >97.0%(T)
Packaging: 5g
Price: $511
Updated: 2025/07/31

TRC

Product number: I918255
Product name: Isoxazolidine Hydrochloride
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: I918255
Product name: Isoxazolidine Hydrochloride
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR55263
Product name: 1,2-Oxazolidinehydrochloride
Packaging: 250mg
Price: $124
Updated: 2021/12/16

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ISOXAZOLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Isoxazolidine Hydrochloride is used to form isoxazolidides by high yield acylation.

Synthesis

142-28-9

39657-45-9

The general procedure for the synthesis of isoxazolidine hydrochloride from 1,3-dichloropropane was as follows: first, 1,3-dichloropropane (1.6 mL, 15 mmol, 1.2 eq.) and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene; 1.8 mL, 12 mmol, 1.0 eq.) were sequentially added to a stirring solution of 2-hydroxyisoindoline-1,3 -dione (N-hydroxyphthalimide; 2.0 g, 12 mmol, 1.0 eq.) in a solution of DMF (30 mL) at a reaction temperature of 23 °C. The reaction mixture was heated to 50 °C and stirred continuously for 18 hours. Upon completion of the reaction, the resulting colorless solution was diluted with 1 M aqueous HCl (300 mL) and extracted with ether (Et2O; 2 x 100 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), gravity filtered and concentrated by rotary evaporation to give a colorless oil (1.5 g). The oil was dissolved in ethanol (EtOH; 15 mL), hydrazine hydrate (300 μL, 11 mmol, 1.0 eq.) was added, and the light yellow suspension was stirred at 23 °C for 4 h. The reaction mixture was filtered under vacuum. The reaction mixture was filtered under vacuum and the filtrate was concentrated by rotary evaporation to give a light yellow powdery product (530 mg, 77% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 5.34 (broad single peak, 2H), 4.07 (triple peak, J = 7 Hz, 2H), 3.37 (triple peak, J = 7 Hz, 2H), 2.30 (quintuple peak, J = 7 Hz, 2H).

References

[1] Patent: US2010/222221, 2010, A1. Location in patent: Page/Page column 7

ISOXAZOLIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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39657-45-9, ISOXAZOLIDINE HYDROCHLORIDERelated Search:

5-Isoxazolecarboxylicacid,ethylester(9CI) ETHYL ISOXAZOLE-3-CARBOXYLATE Isoxazolo[5,4-c]pyridin-3-amine (9CI) 4-hydroxyisoxazole Isoxazolo[4,5-b]pyridin-3-amine (9CI) C-ISOXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE Tolazoline hydrochloride Clomazone DIMETHYL 5-(2,4-DICHLOROPHENYL)-4,6-DIOXOTETRAHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-3,3(3AH)-DICARBOXYLATE 5-(2,4-DICHLOROPHENYL)-2-METHYL-3-PHENYLDIHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-4,6(3H,5H)-DIONE DIMETHYL 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-4,6-DIOXOTETRAHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-3,3(3AH)-DICARBOXYLATE 3-(4-[(4-CHLOROBENZYL)OXY]-3-METHOXYPHENYL)-2-METHYL-4-(PHENYLSULFONYL)TETRAHYDROISOXAZOLE 3A,11C-DIHYDRO-3H-BENZO[5,6]CHROMENO[4,3-C]ISOXAZOL-1(4H)-YL(3,4-DICHLOROPHENYL)METHANONE 2-(4-CHLOROPHENYL)HEXAHYDROPYRROLO[3',4':4,5]ISOXAZOLO[2,3-A]PYRIDINE-1,3(2H,3AH)-DIONE 1-[(4-CHLOROPHENYL)SULFONYL]-1,3A,4,11C-TETRAHYDRO-3H-BENZO[5,6]CHROMENO[4,3-C]ISOXAZOLE (2-METHYL-3-PHENYLTETRAHYDRO-5-ISOXAZOLYL)METHYL 4-CHLOROBENZENECARBOXYLATE 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-3-(4-METHOXYPHENYL)-2-METHYLDIHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-4,6(3H,5H)-DIONE 5-(4-CHLOROPHENYL)-2-([4-HYDROXYDIHYDRO-2(3H)-ISOXAZOLYL]METHYLENE)-1,3-CYCLOHEXANEDIONE

1,2-Oxazolidine hydrochloride

Isoxazolidine, hydrochloride (1:1)

hydrochloride - [K86659]

39657-45-9