ChemicalBook > CAS DataBase List > 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

Uses

Product Name: 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
CAS No.: 1003845-08-6
Chemical Name: 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
Synonyms: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine;2-dioxaborolan-2-yl)pyriMidine;2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER;2-ChloropyriMidin-5-ylboronic acid pinacol ester;2-Chloropyrimidine-5-boronicacidpinacolester,98%;2-chloropyrimidine-5-borate frequency which ol ester;2-Chloropyrimidine-5-boronic acid pinacol ester, 95%,;2-(5-Chloro-2-pyrimidyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(2-Chloro-5-pyrimidinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Pyrimidine, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB62465526
Molecular Formula: C10H14BClN2O2
Formula Weight: 240.49
MOL File: 1003845-08-6.mol

Less

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Property

Melting point:: 65.0 to 69.0 °C
Boiling point:: 369.1±15.0 °C(Predicted)
Density: 1.19±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: -1.68±0.22(Predicted)
color: White to Yellow to Orange

Less

Safety

HS Code: 2933599590

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C3436
Product name: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: C3436
Product name: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $301
Updated: 2025/07/31

TRC

Product number: C428453
Product name: 2-Chloropyrimidine-5-boronicacidpinacolester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W006099
Product name: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: ≥97.0%
Packaging: 5g
Price: $68
Updated: 2021/12/16

AK Scientific

Product number: X1294
Product name: 2-Chloropyrimidine-5-boronicacidpinacolester
Packaging: 250mg
Price: $26
Updated: 2021/12/16

Less

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Uses

Pinacol 2-chloropyrimidine-5-boronate is used to prepare indole derivatives, exhibiting broad pharmacological activity as a selective Pim kinase inhibitor. It is also used to prepare TGF-β1 inhibitors and activin A signal transducers. It is an important chemical product and a key pharmaceutical intermediate.

Synthesis

76-09-5

1003845-06-4

1003845-08-6

34). General procedure for the synthesis of 2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidines: to a mixture of toluene (16 mL) and THF (4 mL) containing 5-bromo-2-chloropyrimidine (10 mmol, 1.93 g) and triisopropyl borate (12 mmol, 2.8 mL) at -78 °C, over a period of Hexane (1.58 M, 12 mmol, 7.6 mL) was added slowly and dropwise over 45 min. The reaction mixture was continued to be stirred at -78 °C for 1 hour. Subsequently, the mixture was slowly warmed to -20 °C and 1 M aqueous hydrochloric acid (20 mL) was added. After continued warming to room temperature, the precipitate was collected and washed with hexane to give a colorless powder (808 mg, 51% yield). A mixture of this powder (3.63 mmol, 575 mg), pinacol (3.81 mmol, 450 mg), and magnesium sulfate (18.15 mmol, 2.2 g) in toluene (10 mL) was stirred at room temperature for 15 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting solid was washed with water to afford the target product 2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine (875 mg, quantitative yield); ESI-MS m/z: 159 [M + 1 - pinacol], retention time 1.75 min (condition A).

References

[1] Patent: WO2008/9435, 2008, A1. Location in patent: Page/Page column 189-190
[2] Patent: US2009/118287, 2009, A1. Location in patent: Page/Page column 67-68

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Suppliers

Americas 1 China 113 Europe 1 France 1 India 3 Japan 1 Switzerland 1 United Kingdom 2 United States 10 Global 133

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Changzhou Chemscaler Pharmtech Co., Ltd.

Tel: 0519-81096292 15312577869
Email: chemscaler@yahoo.com.cn
Country: China
ProdList: 311
Advantage: 60

Bsisun HK Imoprt And Export Company Limited

Tel: +86-18068513926
Fax: 0086-519-85153711
Country: China
ProdList: 1277
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Suzhou Ryan Pharmachem Technology Co.,Ltd

Tel: 0512-66585217 13962137180
Fax: 0512-82177549
Email: sales@ryanchem.com
Country: China
ProdList: 384
Advantage: 55

Nanjing Credit Trading Co.,Ltd

Tel: 025-52164950
Fax: 025-86800069
Email: Googlexu_0114@sina.com
Country: China
ProdList: 644
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9976
Advantage: 58

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Shanghai Rong Lin Medical Technology Co., Ltd.

Tel: 18602194589
Email: lincy-110@163.com
Country: China
ProdList: 863
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4894
Advantage: 55

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Boron Technology (Beijing) Co., Ltd.

Tel: 010-010-15313962280 15313962280
Fax: 010-51669040
Email: 3004509780@qq.com
Country: China
ProdList: 824
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7570
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

LinkChem Technology Co., Ltd.

Tel: 021-58950110 13124863828
Fax: 021-20922272
Email: sales@linkchem.cn
Country: China
ProdList: 2998
Advantage: 58

Combiphos (Shanghai) Biological Technology Co., Ltd.

Tel: 021-65232103 17602124823
Email: combiphos@vip.qq.com
Country: China
ProdList: 30000
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Shengli Biotech Co., Ltd.

Tel: 021-62215214 13621821772
Fax: 021-52261660
Email: 3319226536@qq.com
Country: China
ProdList: 910
Advantage: 58

Nanjing holy chemical co., LTD

Tel: 19951936396
Email: 1815156226@qq.com
Country: China
ProdList: 2947
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 9939
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9987
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Nanjing Hengbei Chemicals Co., Ltd.

Tel: +86-25-58393656
Fax: +86-25-58393656
Email: sales@hengbeichem.cn
Country: China
ProdList: 6854
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Less

View Lastest Price from 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-dioxaborolan-2-yl)pyriMidine 1003845-08-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 1003845-08-6
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-07

1003845-08-6, 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTERRelated Search:

2,4,5-Trichloropyrimidine 2-CHLORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2-FLUOROPHENYLBORONIC ACID, PINACOL ESTER 2-(4-BroMo-2,6-difluoro-phenyl)-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane 1-(3-Methoxypropyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1,2,3,6-tetrahydropyridine 2-(3-BroMo-2-fluoro-phenyl)-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane 1-Isopropyl-1H-pyrazole-5-boronic acid, pinacol ester

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

2-dioxaborolan-2-yl)pyriMidine

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

2-ChloropyriMidin-5-ylboronic acid pinacol ester

2-(2-Chloro-5-pyrimidinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Pyrimidine, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-Chloropyrimidine-5-boronicacidpinacolester,98%

2-(5-Chloro-2-pyrimidyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Chloropyrimidine-5-boronic acid pinacol ester, 95%,

2-chloropyrimidine-5-borate frequency which ol ester

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine - [C15930]

1003845-08-6