TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
Uses- Product Name
- TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
- CAS No.
- 149771-43-7
- Chemical Name
- TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
- Synonyms
- 8-Boc-3-benzyl-3,8-diazabicyclo[3.2.1]octane;3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane;TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE;3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(phenylMethyl)-, 1,1-diMethylethyl ester
- CBNumber
- CB62467656
- Molecular Formula
- C18H26N2O2
- Formula Weight
- 302.41
- MOL File
- 149771-43-7.mol
TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Property
- Boiling point:
- 393.4±35.0 °C(Predicted)
- Density
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 8.57±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1031CW
- Product name
- Tert-butyl3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
- Packaging
- 250mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 175848
- Product name
- tert-Butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- 175848
- Product name
- tert-Butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
- Packaging
- 5g
- Price
- $1296
- Updated
- 2021/12/16
- Product number
- 175848
- Product name
- tert-Butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
- Packaging
- 10g
- Price
- $1872
- Updated
- 2021/12/16
- Product number
- 75R0766
- Product name
- 3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane
- Purity
- 97%
- Packaging
- 5g
- Price
- $2390
- Updated
- 2021/12/16
TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Chemical Properties,Usage,Production
Uses
3-Benzyl-8-(tert-butoxycarbonyl)-3,8-diazabicyclo[3.2.1]-octane is a hydrocarbon derivative that can be used as a pharmaceutical intermediate.
Synthesis
24424-99-5
67571-90-8
149771-43-7
3-Benzyl-3,8-diazabicyclo[3.2.1]octane (13.5 g, 66.7 mmol) was used as starting material and mixed with triethylamine (6.75 g, 66.7 mmol) and di-tert-butyl dicarbonate (14.56 g, 66.7 mmol) in dichloromethane (100 ml). The reaction mixture was stirred under cooling in an ice bath for 3 hours. After completion of the reaction, the crude product was washed with water (150 ml) and the aqueous phase was then extracted with dichloromethane (50 ml). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (13 g, 65% yield). The melting point of the product was 58-60°C.
References
[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 674 - 681
[2] Farmaco, 1993, vol. 48, # 3, p. 387 - 396
[3] Patent: EP1213289, 2002, A1. Location in patent: Page 12
[4] Patent: WO2006/106090, 2006, A1. Location in patent: Page/Page column 16
[5] Farmaco, 1998, vol. 53, # 8-9, p. 557 - 562
TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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