5,6-difluoroindoline

Product Name: 5,6-difluoroindoline
CAS No.: 954255-04-0
Chemical Name: 5,6-difluoroindoline
Synonyms: 5,6-difluoroindoline;5,6-difluoro-2,3-dihydro-1H-indole;1H-Indole, 5,6-difluoro-2,3-dihydro-
CBNumber: CB62470625
Molecular Formula: C8H7F2N
Formula Weight: 155.14
MOL File: 954255-04-0.mol

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5,6-difluoroindoline Property

Boiling point:: 207.0±40.0 °C(Predicted)
Density: 1.261±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.30±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D456245
Product name: 5,6-Difluoroindoline
Packaging: 50mg
Price: $155
Updated: 2021/12/16

TRC

Product number: D456245
Product name: 5,6-Difluoroindoline
Packaging: 100mg
Price: $220
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-6A
Product name: 5,6-Difluoroindoline
Purity: 97%
Packaging: 250mg
Price: $223
Updated: 2021/12/16

Matrix Scientific

Product number: 090267
Product name: 5,6-Difluoroindoline
Purity: 95+%
Packaging: 250mg
Price: $319
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0054134
Product name: 5,6-DIFLUOROINDOLINE
Purity: 95.00%
Packaging: 250MG
Price: $425.25
Updated: 2021/12/16

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5,6-difluoroindoline Chemical Properties,Usage,Production

Synthesis

169674-01-5

954255-04-0

General procedure for the synthesis of 5,6-difluoroindoline from 5,6-difluoroindole: 0.30 g (1.8 mmol) of 5,6-difluoroindole was dissolved in 10 mL of tetrahydrofuran (THF) under the protection of argon gas and 3.0 mL of 1 M borane-THF solution was added slowly and dropwise. Subsequently, the reaction mixture was heated to 70 °C and maintained for 2 h, after which it was cooled to room temperature. To the reaction mixture, 3 mL of methanol was added, followed by 5 mL of aqueous 4N hydrochloric acid solution, and the mixture was refluxed for 1 hour. Upon completion of the reaction, the organic phase was removed by evaporation and the aqueous phase was washed with dichloromethane (DCM) and then alkalized with 4N aqueous sodium hydroxide solution, followed by multiple extractions with ethyl acetate (EtOAc). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The product was obtained as 160 mg in 47% yield. eSI-MS: m/z = 156 (M + H)+; HPLC-MS retention time (Method C): 0.73 min.

References

[1] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 47

5,6-difluoroindoline Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-difluoroindoline Suppliers

China 47 India 1 United States 7 Global 55

Carbott PharmTech Inc.

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Biokitchen

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View Lastest Price from 5,6-difluoroindoline manufacturers

Career Henan Chemical Co

Product: 5,6-difluoroindoline 954255-04-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

954255-04-0, 5,6-difluoroindolineRelated Search:

5,6-difluoroindoline

5,6-difluoro-2,3-dihydro-1H-indole

1H-Indole, 5,6-difluoro-2,3-dihydro-

954255-04-0