5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Product Name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- CAS No.
- 923595-58-8
- Chemical Name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Synonyms
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidine, 5-chloro-3-iodo-;5-chloro-3-iodopyrazole and [1, 5-a] pyrimidine;5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB62471516
- Molecular Formula
- C6H3ClIN3
- Formula Weight
- 279.47
- MOL File
- 923595-58-8.mol
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine Property
- Density
- 2.34±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -2.38±0.40(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C371600
- Product name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C371600
- Product name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C371600
- Product name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FC142158
- Product name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Packaging
- 100mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 073725
- Product name
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine Chemical Properties,Usage,Production
Synthesis
29274-24-6
923595-58-8
The general procedure for the synthesis of 5-chloro-3-iodopyrazolo[1,5-a]pyrimidines from 5-chloropyrazolo[1,5-a]pyrimidines was as follows: 5-chloropyrazolo[1,5-a]pyrimidines (200 mg, 1.30 mmol) were dissolved in N,N-dimethylformamide (DMF, 2 mL), followed by the addition of N-iodosuccinimides (NIS, 322 mg. 1.86 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction solution was diluted with ethyl acetate (EtOAc, 100 mL) and washed sequentially with water (50 mL), saturated aqueous sodium thiosulfate (Na2S2O3) (50 mL) and saturated saline (50 mL). The organic phase was separated, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (v/v = 1/4) to afford 5-chloro-3-iodopyrazolo[1,5-a]pyrimidine as a light yellow solid (390 mg, 100% yield). Mass spectrum (ESI, positive ion mode) m/z: 279.9 [M + H]+. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.57 (d, J = 7.2 Hz, 1H), 8.16 (s, 1H), 6.86 (d, J = 7.2 Hz, 1H).
References
[1] Patent: US2014/234254, 2014, A1. Location in patent: Paragraph 0308; 0309; 0310
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0439; 0441; 0442
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6280 - 6296
[4] Patent: WO2007/13673, 2007, A1. Location in patent: Page/Page column 31
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine manufacturers
- Product
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine 923595-58-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine 923595-58-8
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%-99%
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-07