PROTRIPTYLINE HYDROCHLORIDE Property

Melting point:

169-171°

Flash point:

9℃

storage temp. 

2-8°C

solubility 

H2O: soluble50mg/mL

pka

8.2(at 25℃)

form 

powder

color 

white to off-white

Stability:

Hygroscopic

Safety

Hazard Codes 

Xn,T,F

Risk Statements 

20/21/22-36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

26-36-45-36/37-16-7

RIDADR 

3249

WGK Germany 

3

RTECS 

HP1400000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2921490002

Toxicity

dog,LDLo,oral,400mg/kg (400mg/kg),"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

PROTRIPTYLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

brand name

Vivactil (Odyssey).

General Description

Protriptyline hydrochloride, N-methyl-5H-dibenzo[a,d]-cycloheptene-5-propylamine hydrochloride, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene hydrochloride(Vivactil), like the other compounds under consideration, isan effective antidepressant. The basis for its chemical namingcan be seen by consulting the naming and the structureof imipramine. Protriptyline is a structural isomer of nortriptyline.Inactivation can be expected to involve the relativelylocalized double bond. Because it is a monomethylcompound, its sedative potential is low.

Biochem/physiol Actions

Norepinephrine uptake blocker.