ChemicalBook > CAS DataBase List > 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

Product Name
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
CAS No.
223488-57-1
Chemical Name
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
Synonyms
CS-2325;CP-533536;Evatanepag;CP-533536 free acid;Evatanepag (CP-533536);Evatanepag, 10 mM in DMSO;CP-533536;CP 533536;CP533536;EVATANEPAG;CP-533536;CP 533536;2-(3-((N-(4-(tert-Butyl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid;2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
CBNumber
CB62484828
Molecular Formula
C25H28N2O5S
Formula Weight
468.57
MOL File
223488-57-1.mol
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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:32.0(Max Conc. mg/mL);68.29(Max Conc. mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5571
Product name
Evatanepag
Purity
99.80%
Packaging
5mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006002
Product name
CP-533536
Purity
95.00%
Packaging
5MG
Price
$497.45
Updated
2021/12/16
ChemScene
Product number
CS-5571
Product name
Evatanepag
Purity
99.80%
Packaging
10mg
Price
$600
Updated
2021/12/16
AK Scientific
Product number
4016CR
Product name
Evatanepag
Packaging
2mg
Price
$611
Updated
2021/12/16
ChemScene
Product number
CS-5571
Product name
Evatanepag
Purity
99.80%
Packaging
1mg
Price
$180
Updated
2021/12/16
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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Chemical Properties,Usage,Production

Uses

Evatanepag is an EP2 receptor selective prostaglandin E2 agonist that helps induce bone growth.

Definition

ChEBI: Evatanepag is a monocarboxylic acid.

in vivo

Evatanepag (0.3-3.0 mg/kg, directly injected into the marrow cavity of the tibia) promotes bone formation in rats[1].
Evatanepag (0.3, 3.0 mg/kg, intranasal administration, from day1 to day4) reduces HDM aeroallergen-induced increased RL response to methacholine in mice[2].
Evatanepag (1 mg/kg, intravenous injection) demonstrates high i.v. clearance (Cl: 56 mL/min/kg) and a short half-life (t1/2: 0.33 h)[1].

Animal Model:Rats[1]
Dosage:0.3, 1.0, 3.0 mg/kg
Administration:Directly injected into the marrow cavity of the tibia
Result:Dose-dependently increased in bone area, bone mineral content, bone mineral density.
Animal Model:HDM (house dust mite)-sensitized BALB/c mice[2]
Dosage:0.3 mg/kg, 3 mg/kg
Administration:Intranasal administration, from day1 to day4
Result:Prevented aeroallergen-driven increased RL (lung resistance) at 0.3 mg/kg.
Prevented the enhanced MC activity by approximately 48% at 3 mg/kg.

IC 50

EP2

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Suppliers

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View Lastest Price from 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid 223488-57-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Career Henan Chemical Co
Product
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid 223488-57-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

223488-57-1, 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acidRelated Search:

N-Methylformamide

  • EVATANEPAG;CP-533536;CP 533536
  • CP-533536;CP 533536;CP533536
  • (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid
  • Evatanepag (CP-533536)
  • CS-2325
  • 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
  • CP-533536
  • Evatanepag
  • CP-533536 free acid
  • Acetic acid, 2-[3-[[[[4-(1,1-dimethylethyl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-
  • 2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]aceticaci
  • 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid ISO 9001：2015 REACH
  • HDM,asthma,CP533536,mast cell,CP-533536,CP 533536,Evatanepag,bone,Prostaglandin Receptor,Inhibitor,Fracture healing,allergy,inflammation,inhibit
  • 2-(3-((N-(4-(tert-Butyl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid
  • 2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid
  • Evatanepag, 10 mM in DMSO
  • 223488-57-1