1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- Product Name
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- CAS No.
- 3543-73-5
- Chemical Name
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- Synonyms
- ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
- CBNumber
- CB62485092
- Molecular Formula
- C14H19N3O2
- Formula Weight
- 261.32
- MOL File
- 3543-73-5.mol
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Property
- Melting point:
- 130-135°C
- Boiling point:
- 471.6±25.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 6.73±0.10(Predicted)
- color
- Off-White to Pale Beige
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M285645
- Product name
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoicAcidEthylEster
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 102756
- Product name
- Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
- Purity
- >97%
- Packaging
- 1g
- Price
- $92
- Updated
- 2021/12/16
- Product number
- J97551
- Product name
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoicacidethylester
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 102756
- Product name
- Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
- Purity
- >97%
- Packaging
- 5g
- Price
- $342
- Updated
- 2021/12/16
- Product number
- 4H58-1-CV
- Product name
- Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
- Packaging
- 1g
- Price
- $436
- Updated
- 2021/12/16
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.
Synthesis
In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers
View Lastest Price from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers
- Product
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 3543-73-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-17