ChemicalBook > CAS DataBase List > 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Product Name
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
CAS No.
3543-73-5
Chemical Name
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
Synonyms
ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
CBNumber
CB62485092
Molecular Formula
C14H19N3O2
Formula Weight
261.32
MOL File
3543-73-5.mol
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1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Property

Melting point:
130-135°C
Boiling point:
471.6±25.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
6.73±0.10(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C14H19N3O2/c1-3-19-14(18)6-4-5-13-16-11-9-10(15)7-8-12(11)17(13)2/h7-9H,3-6,15H2,1-2H3
InChIKey
JUMGOLYNZBZPKE-UHFFFAOYSA-N
SMILES
C1(CCCC(OCC)=O)N(C)C2=CC=C(N)C=C2N=1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M285645
Product name
1-Methyl-5-amino-1H-benzimidazole-2-butanoicAcidEthylEster
Packaging
5mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
102756
Product name
Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
Purity
>97%
Packaging
1g
Price
$92
Updated
2021/12/16
AK Scientific
Product number
J97551
Product name
1-Methyl-5-amino-1H-benzimidazole-2-butanoicacidethylester
Packaging
1g
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
102756
Product name
Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
Purity
>97%
Packaging
5g
Price
$342
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-CV
Product name
Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
Packaging
1g
Price
$436
Updated
2021/12/16
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1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.

Synthesis

In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers

Career Henan Chemical Co
Product
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 3543-73-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-17

3543-73-5, 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl esterRelated Search:

FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate

  • 5-AMINO-1-METHYL-1H-BENZIMIDAZOLE-2-BUTANOIC ACID ETHYL ESTER
  • Ethyl-4-(5-aMino-1-Methy-1H-benzo[d] iMidazol-2-yl)butanoate
  • 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
  • ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
  • 4-(5-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acidethylester
  • 5-amino-1-methyl-2-Benzimidazolebutyric acid ethyl ester
  • 5-AMino-1-Methyl-
  • 4-[5-AMino-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
  • 1-Methyl-5-aMino-1H-benziMidazole-2-butanoic acid ethyl este
  • BendaMustine hydrochloride interMediate
  • 4-(5-aMino-1-Methyl-1H-benzoiMidazol-2-yl)-butyric acid ethyl esterCAS
  • BendaMustine Dideschloroethyl Ethyl Ester
  • ethyl 4-(5-aMino-1-Methyl-1H-1,3-benzodiazol-2-yl)butanoate
  • ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate
  • Bendamustine Intermediate
  • Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
  • Bendamustine hydrochloride Intermediates 2
  • 5-(5-amino-1-methyl-2-benzimidazolyl)-1-methoxy-2-pentanone
  • 4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate
  • 1-Methyl-5-amino-1H-benzimidazole-2
  • endamustine Dideschloroethyl Ethyl Ester
  • 1H-Benzimidazole-2-butanoic acid, 5-amino-1-methyl-, ethyl ester
  • Ethyl4-(5-amino-1-methyl-1Hbenzo[d]imidazole -2-yl)butanoate
  • ETHYL 4-(5-AMINO-1-METHYL-1HBENZIMIDAZOL-2-YL) BUTANOATE
  • Bendamustine Hydrochloride Intermediate 3543-73-5 API Manufacturer
  • Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
  • 3543-73-5
  • Aromatics
  • Heterocycles
  • Intermediates