2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- Product Name
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- CAS No.
- 1053228-28-6
- Chemical Name
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- Synonyms
- EOS-60657;cas no 1053228-28-6;cas no 1053228-28-6 for sale;cas no 1053228-28-6 price USD;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro-;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid, 10 mM in DMSO;2,4,5Trichloro7Hpyrrolo[2,3d]pyrimid,2,4,5 Trichloro 7H pyrrolo[2,3 d]pyrimid
- CBNumber
- CB62489641
- Molecular Formula
- C6H2Cl3N3
- Formula Weight
- 222.46
- MOL File
- 1053228-28-6.mol
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Property
- Melting point:
- 225 °C(Solv: dichloromethane (75-09-2))
- Density
- 1.791±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.69±0.50(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T774213
- Product name
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- T774213
- Product name
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- HCH0362612
- Product name
- 2,4,5-TRICHLORO-7H-PYRROLO-[2,3-D]PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.67
- Updated
- 2021/12/16
- Product number
- CS-W003858
- Product name
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 97.13%
- Packaging
- 25g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- X8750
- Product name
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $131.6
- Updated
- 2021/12/16
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
90213-66-4
1053228-28-6
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (2.0 g, 10.64 mmol) was used as a starting material, which was dissolved in dichloromethane/tetrahydrofuran (DCM/THF, 15 mL/6 mL) mixed solvent. Subsequently, N-chlorosuccinimide (NCS, 1.70 g, 12.76 mmol) was added to the solution. The reaction mixture was placed in a microwave reactor, heated to 90 °C and kept at this temperature for 2.5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by fast column chromatography with the eluent being a 9:1 (v/v) hexane/ethyl acetate solvent mixture to afford 2,4,5-trichloro-7H-pyrrolo[2,3-d]pyrimidine (2.2 g, 93% yield) as a white crystalline solid. Mass spectrometry (MS) analysis showed m/z 223.48 [M + 1].
References
[1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 584 - 589
[3] Patent: WO2016/130920, 2016, A2. Location in patent: Page/Page column 115
[4] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 127
[5] Organic Letters, 2016, vol. 18, # 9, p. 1976 - 1979
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers
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- 001-857-928-2050 or 1-888-588-9418
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View Lastest Price from 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers
- Product
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyriMidine 1053228-28-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine 1053228-28-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08