ChemicalBook > CAS DataBase List > 3,5-Dichloropyrazine-2-carbonitrile

3,5-Dichloropyrazine-2-carbonitrile

Uses

Product Name: 3,5-Dichloropyrazine-2-carbonitrile
CAS No.: 313339-92-3
Chemical Name: 3,5-Dichloropyrazine-2-carbonitrile
Synonyms: 3,5-Dichloropyrazinecarbonitrile;3,5-Dichloro-2-pyrazinecarbonitrile;5-dichloropyrazine-2-carbonitrile;1,3-Propanediol,1-(5-piperidinyl)-;3,5-Dichloropyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 3,5-dichloro-;3,5-Dichloropyrazine-2-carbonitrile ISO 9001：2015 REACH;2-Cyano-3,5-dichloropyrazine, 2-Cyano-3,5-dichloro-1,4-diazin;2-Cyano-3,5-dichloropyrazine, 2-Cyano-3,5-dichloro-1,4-diazine
CBNumber: CB62489661
Molecular Formula: C5HCl2N3
Formula Weight: 173.99
MOL File: 313339-92-3.mol

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3,5-Dichloropyrazine-2-carbonitrile Property

Boiling point:: 277℃
Density: 1.60
Flash point:: 121℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -8.85±0.10(Predicted)
form: solid
color: White
InChI: InChI=1S/C5HCl2N3/c6-4-2-9-3(1-8)5(7)10-4/h2H
InChIKey: SDTCGHLDTSGIRR-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=C(Cl)N=C1Cl

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D437140
Product name: 3,5-Dichloropyrazine-2-carbonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 073768
Product name: 3,5-Dichloropyrazine-2-carbonitrile
Purity: 95+%
Packaging: 1g
Price: $69
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: D13904
Product name: 3,5-Dichloropyrazine-2-carbonitrile
Packaging: 1g
Price: $15
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD138213
Product name: 3,5-Dichloropyrazine-2-carbonitrile
Packaging: 1g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD138213
Product name: 3,5-Dichloropyrazine-2-carbonitrile
Packaging: 2g
Price: $120
Updated: 2021/12/16

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3,5-Dichloropyrazine-2-carbonitrile Chemical Properties,Usage,Production

Uses

3,5-Dichloropyrazine-2-carboxynitrile is a chemical intermediate.

Synthesis

312736-50-8

313339-92-3

General procedure for the synthesis of 3,5-dichloropyrazine-2-carbonitrile from 3,5-dichloropyrazine-2-carboxamide: To a solution of acetonitrile (100 mL) of 3,5-dichloropyrazine-2-carboxamide (5.0 g, 13.3 mmol) obtained in Preparation Example 13.1 was added phosphorous triclorethylene (6.76 mL, 72.3 mmol), and the reaction was stirred for 4 hr at 80 °C. Upon completion of the reaction, the reaction mixture was diluted with water and subsequently extracted with ethyl acetate and the organic layer was washed with saturated saline. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: 20% n-hexane/ethyl acetate) to afford 3,5-dichloropyrazine-2-carbonitrile (2.94 g, 65% yield) as a solid.

References

[1] Organic Letters, 2013, vol. 15, # 9, p. 2156 - 2159
[2] Patent: WO2016/6975, 2016, A2. Location in patent: Paragraph 461-463
[3] Patent: KR2016/7347, 2016, A. Location in patent: Paragraph 0359; 0363; 0364; 0365
[4] Patent: WO2018/22992, 2018, A1. Location in patent: Paragraph 0725; 0726
[5] Patent: US2018/72743, 2018, A1. Location in patent: Paragraph 1330-1331

3,5-Dichloropyrazine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Dichloropyrazine-2-carbonitrile manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3,5-Dichloropyrazine-2-carbonitrile 313339-92-3
Price: US $10.00-3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-26

Career Henan Chemical Co

Product: 3,5-Dichloropyrazine-2-carbonitrile 313339-92-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-11

313339-92-3, 3,5-Dichloropyrazine-2-carbonitrileRelated Search:

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3,5-Dichloro-2-pyrazinecarbonitrile

3,5-Dichloropyrazinecarbonitrile

3,5-Dichloropyrazine-2-carbonitrile

2-Cyano-3,5-dichloropyrazine, 2-Cyano-3,5-dichloro-1,4-diazine

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3,5-Dichloropyrazine-2-carbonitrile ISO 9001：2015 REACH

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313339-92-3