2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- Product Name
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- CAS No.
- 487-66-1
- Chemical Name
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- Synonyms
- 2-propionic-3-methylmaleic anhydride;2-(2-Carboxyethyl)-3-methylmaleic Anhydride;3-(4-methyl-2,5-dioxo-3-furyl)propanoic acid;3-(4-methyl-2,5-dioxofuran-3-yl)propanoic acid;2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid;3-Furanpropanoic acid, 2,5-dihydro-4-methyl-2,5-dioxo-;2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoicAcid>3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid;3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid (Related Reference)
- CBNumber
- CB62491082
- Molecular Formula
- C8H8O5
- Formula Weight
- 184.15
- MOL File
- 487-66-1.mol
2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid Property
- Melting point:
- 97.0 to 101.0 °C
- Boiling point:
- 391.0±25.0 °C(Predicted)
- Density
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 4.31±0.10(Predicted)
- color
- White to Almost white
Safety
- HS Code
- 2932.19.5100
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D3955
- Product name
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $209
- Updated
- 2025/07/31
- Product number
- D3955
- Product name
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $834
- Updated
- 2025/07/31
- Product number
- D680028
- Product name
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 5366AL
- Product name
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- A664682
- Product name
- 3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid Chemical Properties,Usage,Production
Synthesis
13192-04-6
3699-66-9
487-66-1
Example 4: Synthesis of Masking Agent A - Preparation of 2-propanoic acid-3-methylmaleic anhydride (carboxydimethylmaleic anhydride or CDM) precursor 1. Suspend sodium hydride (0.58 g, 25 mmol) in 50 mL of anhydrous tetrahydrofuran to which triethyl 2-phosphonopropyl ester (7.1 g, 30 mmol) was added. After the hydrogen release stopped, dimethyl α-ketoglutarate (15 g, 20 mmol) dissolved in 10 mL of anhydrous tetrahydrofuran was added and the reaction mixture was stirred for 30 minutes. 2. Upon completion of the reaction, 10 mL of water was added and the tetrahydrofuran was removed by rotary evaporation. The resulting solid-water mixture was extracted with ether (3 x 50 mL). The ether layers were combined, dried with magnesium sulfate and concentrated to give a light yellow oil. 3. The above oil was purified by silica gel column chromatography with the eluent of ether:hexane (2:1) to give 4 g of pure triglyceride (82% yield). 4. The resulting triglyceride was dissolved in 50 mL of a solvent mixture of water and ethanol (ratio 50:150) and potassium hydroxide (4.5 g, 5 eq.) was added. The reaction mixture was heated to reflux for 1 hour. 5. Upon completion of the reaction, the ethanol was removed by rotary evaporation and the solution was acidified with hydrochloric acid to pH 2. Subsequently, the aqueous solution was extracted with ethyl acetate (200 mL), the organic layer was separated, dried with magnesium sulfate and concentrated to give a white solid. 6. Finally, the white solid was recrystallized by dichloromethane and hexane to give 2 g of 2-propanoic acid-3-methylmaleic anhydride (80% yield).
References
[1] Patent: US9249179, 2016, B2. Location in patent: Page/Page column 35; 36
2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid manufacturers
- Product
- 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid 487-66-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-10-14