ChemicalBook > CAS DataBase List > methyl 2-chloroquinoline-6-carboxylate

methyl 2-chloroquinoline-6-carboxylate

Product Name
methyl 2-chloroquinoline-6-carboxylate
CAS No.
849807-09-6
Chemical Name
methyl 2-chloroquinoline-6-carboxylate
Synonyms
methyl 2-chloroquinoline-6-carboxylate ;2-Chloro-quinoline-6-carboxylic acid methyl ester;6-Quinolinecarboxylic acid, 2-chloro-, methyl ester
CBNumber
CB62491668
Molecular Formula
C11H8ClNO2
Formula Weight
221.64
MOL File
849807-09-6.mol
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methyl 2-chloroquinoline-6-carboxylate Property

Melting point:
134-136 °C(Solv: chloroform (67-66-3))
Boiling point:
343.7±22.0 °C(Predicted)
Density 
1.330±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
-0.60±0.43(Predicted)
Appearance
Off-white to brown Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
35072
Product name
Methyl2-chloroquinoline-6-carboxylate
Purity
95+%
Packaging
1000mg
Price
$720
Updated
2021/12/16
AK Scientific
Product number
Y5574
Product name
Methyl2-chloroquinoline-6-carboxylate
Packaging
1g
Price
$388
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0369194
Product name
METHYL-2-CHLOROQUINOLINE-6-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$502.66
Updated
2021/12/16
AK Scientific
Product number
Y5574
Product name
Methyl2-chloroquinoline-6-carboxylate
Packaging
10g
Price
$1603
Updated
2021/12/16
Crysdot
Product number
CD11046587
Product name
Methyl2-chloroquinoline-6-carboxylate
Purity
98%
Packaging
25g
Price
$2159
Updated
2021/12/16
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methyl 2-chloroquinoline-6-carboxylate Chemical Properties,Usage,Production

Synthesis

358368-09-9

849807-09-6

To a dichloromethane solution of 2-chloroquinoline-6-carboxylic acid (4.0 g, 20 mmol) and N,N-dimethylformamide (8 ml) was slowly added sulfoxide chloride (8 ml) at 0°C and the reaction mixture was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was concentrated to give a residue. The residue was dissolved in dichloromethane (50 ml) and washed with saturated sodium bicarbonate solution (20 ml) and stirred for 30 minutes. The organic layer was separated and concentrated to give the crude product. The crude product was purified by silica gel column chromatography to afford methyl 2-chloroquinoline-6-carboxylate (1.3 g, 30% yield) as a white solid.

References

[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 8, p. 1606 - 1611
[2] Patent: US2014/128391, 2014, A1. Location in patent: Paragraph 0188; 0191; 0192; 0282; 0285; 0286
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 12, p. 3573 - 3578
[4] Heterocycles, 2011, vol. 83, # 7, p. 1649 - 1658
[5] Patent: WO2016/7423, 2016, A1. Location in patent: Page/Page column 45

methyl 2-chloroquinoline-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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849807-09-6, methyl 2-chloroquinoline-6-carboxylate Related Search:


  • methyl 2-chloroquinoline-6-carboxylate
  • 6-Quinolinecarboxylic acid, 2-chloro-, methyl ester
  • 2-Chloro-quinoline-6-carboxylic acid methyl ester
  • 849807-09-6