methyl 2-chloroquinoline-6-carboxylate
- Product Name
- methyl 2-chloroquinoline-6-carboxylate
- CAS No.
- 849807-09-6
- Chemical Name
- methyl 2-chloroquinoline-6-carboxylate
- Synonyms
- methyl 2-chloroquinoline-6-carboxylate ;2-Chloro-quinoline-6-carboxylic acid methyl ester;6-Quinolinecarboxylic acid, 2-chloro-, methyl ester
- CBNumber
- CB62491668
- Molecular Formula
- C11H8ClNO2
- Formula Weight
- 221.64
- MOL File
- 849807-09-6.mol
methyl 2-chloroquinoline-6-carboxylate Property
- Melting point:
- 134-136 °C(Solv: chloroform (67-66-3))
- Boiling point:
- 343.7±22.0 °C(Predicted)
- Density
- 1.330±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.60±0.43(Predicted)
- Appearance
- Off-white to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 35072
- Product name
- Methyl2-chloroquinoline-6-carboxylate
- Purity
- 95+%
- Packaging
- 1000mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- Y5574
- Product name
- Methyl2-chloroquinoline-6-carboxylate
- Packaging
- 1g
- Price
- $388
- Updated
- 2021/12/16
- Product number
- HCH0369194
- Product name
- METHYL-2-CHLOROQUINOLINE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.66
- Updated
- 2021/12/16
- Product number
- Y5574
- Product name
- Methyl2-chloroquinoline-6-carboxylate
- Packaging
- 10g
- Price
- $1603
- Updated
- 2021/12/16
- Product number
- CD11046587
- Product name
- Methyl2-chloroquinoline-6-carboxylate
- Purity
- 98%
- Packaging
- 25g
- Price
- $2159
- Updated
- 2021/12/16
methyl 2-chloroquinoline-6-carboxylate Chemical Properties,Usage,Production
Synthesis
358368-09-9
849807-09-6
To a dichloromethane solution of 2-chloroquinoline-6-carboxylic acid (4.0 g, 20 mmol) and N,N-dimethylformamide (8 ml) was slowly added sulfoxide chloride (8 ml) at 0°C and the reaction mixture was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was concentrated to give a residue. The residue was dissolved in dichloromethane (50 ml) and washed with saturated sodium bicarbonate solution (20 ml) and stirred for 30 minutes. The organic layer was separated and concentrated to give the crude product. The crude product was purified by silica gel column chromatography to afford methyl 2-chloroquinoline-6-carboxylate (1.3 g, 30% yield) as a white solid.
References
[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 8, p. 1606 - 1611
[2] Patent: US2014/128391, 2014, A1. Location in patent: Paragraph 0188; 0191; 0192; 0282; 0285; 0286
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 12, p. 3573 - 3578
[4] Heterocycles, 2011, vol. 83, # 7, p. 1649 - 1658
[5] Patent: WO2016/7423, 2016, A1. Location in patent: Page/Page column 45
methyl 2-chloroquinoline-6-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 2-chloroquinoline-6-carboxylate Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30