oglemilast

Product Name: oglemilast
CAS No.: 778576-62-8
Chemical Name: oglemilast
Synonyms: GRC 3886;oglemilast;GRC 3886;GRC-3886;GRC3886;oglemilast ISO 9001：2015 REACH;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carb;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxa;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide;1-Dibenzofurancarboxamide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-8-[(methylsulfonyl)amino]-;N-(3,5-Dichloropyridin-4-yl)-4-difluoromethoxy-8-[(methylsulfonyl)amino]dibenzo[b,d]furan-1-carboxamide;4-DifluoroMethoxy-8-MethanesulfonylaMino-dibenzofuran-1-carboxylic acid (3,5-dichloro-pyridin-4-yl)-aMide
CBNumber: CB62498829
Molecular Formula: C20H13Cl2F2N3O5S
Formula Weight: 516.3
MOL File: 778576-62-8.mol

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oglemilast Property

Density: 1.653
storage temp.: Store at -20°C
solubility: DMSO : 4 mg/mL (7.75 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 7.10±0.30(Predicted)
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FO65110
Product name: Oglemilast
Packaging: 5mg
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-0844
Product name: Oglemilast
Purity: 98.20%
Packaging: 5mg
Price: $182
Updated: 2021/12/16

ChemScene

Product number: CS-0844
Product name: Oglemilast
Purity: 98.20%
Packaging: 10mg
Price: $307
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0019504
Product name: N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)-8-(METHYLSULFONAMIDO)DIBENZO[B,D]FURAN-1-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.92
Updated: 2021/12/16

ChemScene

Product number: CS-0844
Product name: Oglemilast
Purity: 98.20%
Packaging: 50mg
Price: $612
Updated: 2021/12/16

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oglemilast Chemical Properties,Usage,Production

Uses

Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases[1][2][3].

target

PDE4

IC 50

PDE4D3: .5 nM (IC₅₀)

References

[1] Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. DOI:10.1038/bjp.2008.297
[2] Rabe KF, et al. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol. 2011 May;163(1):53-67. DOI:10.1111/j.1476-5381.2011.01218.x
[3] Wunder F, et al. Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter celllines. Mol Pharm. 2013 Oct 7;10(10):3697-705. DOI:10.1021/mp400206m

oglemilast Preparation Products And Raw materials

Raw materials

Preparation Products

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oglemilast Suppliers

China 66 United Kingdom 3 United States 7 Global 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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MedChemexpress LLC

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Email: sales@medchemexpress.cn
Country: United States
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LETOPHARM LIMITED

Tel: +86-21-5821 5861
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Email: sales@letopharm.com
Country: China
ProdList: 2384
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SPIRO PHARMA

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Country: China
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Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
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Guangzhou QiYun Biotechnology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Chengdu Huachun Technology Co., Ltd

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Email: cdhxsj@163.com
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ProdList: 14603
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9126
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View Lastest Price from oglemilast manufacturers

Dideu Industries Group Limited

Product: oglemilast 778576-62-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-07

778576-62-8, oglemilastRelated Search:

GRC 3886

oglemilast

4-DifluoroMethoxy-8-MethanesulfonylaMino-dibenzofuran-1-carboxylic acid (3,5-dichloro-pyridin-4-yl)-aMide

N-(3,5-Dichloropyridin-4-yl)-4-difluoromethoxy-8-[(methylsulfonyl)amino]dibenzo[b,d]furan-1-carboxamide

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxa

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carb

GRC 3886;GRC-3886;GRC3886

1-Dibenzofurancarboxamide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-8-[(methylsulfonyl)amino]-

oglemilast ISO 9001：2015 REACH

778576-62-8

C20H13Cl2F2N3O5S