oglemilast
- Product Name
- oglemilast
- CAS No.
- 778576-62-8
- Chemical Name
- oglemilast
- Synonyms
- GRC 3886;oglemilast;GRC 3886;GRC-3886;GRC3886;oglemilast ISO 9001：2015 REACH;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carb;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxa;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide;1-Dibenzofurancarboxamide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-8-[(methylsulfonyl)amino]-;N-(3,5-Dichloropyridin-4-yl)-4-difluoromethoxy-8-[(methylsulfonyl)amino]dibenzo[b,d]furan-1-carboxamide;4-DifluoroMethoxy-8-MethanesulfonylaMino-dibenzofuran-1-carboxylic acid (3,5-dichloro-pyridin-4-yl)-aMide
- CBNumber
- CB62498829
- Molecular Formula
- C20H13Cl2F2N3O5S
- Formula Weight
- 516.3
- MOL File
- 778576-62-8.mol
oglemilast Property
- Density
- 1.653
- storage temp.
- Store at -20°C
- solubility
- DMSO : 4 mg/mL (7.75 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- 7.10±0.30(Predicted)
- color
- Light yellow to khaki
N-Bromosuccinimide Price
- Product number
- FO65110
- Product name
- Oglemilast
- Packaging
- 5mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CS-0844
- Product name
- Oglemilast
- Purity
- 98.20%
- Packaging
- 5mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- CS-0844
- Product name
- Oglemilast
- Purity
- 98.20%
- Packaging
- 10mg
- Price
- $307
- Updated
- 2021/12/16
- Product number
- API0019504
- Product name
- N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)-8-(METHYLSULFONAMIDO)DIBENZO[B,D]FURAN-1-CARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.92
- Updated
- 2021/12/16
- Product number
- CS-0844
- Product name
- Oglemilast
- Purity
- 98.20%
- Packaging
- 50mg
- Price
- $612
- Updated
- 2021/12/16
oglemilast Chemical Properties,Usage,Production
Uses
Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases[1][2][3].
target
PDE4
IC 50
PDE4D3: .5 nM (IC50)
References
[1] Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. DOI:10.1038/bjp.2008.297
[2] Rabe KF, et al. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol. 2011 May;163(1):53-67. DOI:10.1111/j.1476-5381.2011.01218.x
[3] Wunder F, et al. Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter celllines. Mol Pharm. 2013 Oct 7;10(10):3697-705. DOI:10.1021/mp400206m
oglemilast Preparation Products And Raw materials
Raw materials
Preparation Products
oglemilast Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@glenthamls.com
- Country
- United Kingdom
- ProdList
- 1429
- Advantage
- 0
- Tel
- --
- Fax
- --
- sales@seqchem.com
- Country
- United Kingdom
- ProdList
- 3113
- Advantage
- 69
View Lastest Price from oglemilast manufacturers
- Product
- oglemilast 778576-62-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07