N-Boc-1-amino-cyclobutyl-methanol
- Product Name
- N-Boc-1-amino-cyclobutyl-methanol
- CAS No.
- 1142211-17-3
- Chemical Name
- N-Boc-1-amino-cyclobutyl-methanol
- Synonyms
- 1-(Boc-amino)cyclobutylmethanol;N-Boc-1-amino-cyclobutyl-methanol;N-Boc-1-(hydroxyMethyl)cyclobutylaMine;Tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate;(1-hydroxyMethylcyclobutyl)carbaMic acid tert-butyl ester;tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate - [B16756];N-[1-(Hydroxymethyl)cyclobutyl]-carbamic acid tert-butyl ester;Carbamic acid, N-[1-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB62502809
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 1142211-17-3.mol
N-Boc-1-amino-cyclobutyl-methanol Property
- Boiling point:
- 312.2±11.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.12±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H19NO3/c1-9(2,3)14-8(13)11-10(7-12)5-4-6-10/h12H,4-7H2,1-3H3,(H,11,13)
- InChIKey
- CLRGYDRXIYIAHC-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1(CO)CCC1
Safety
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B603240
- Product name
- N-Boc-1-amino-cyclobutyl-methanol
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B603240
- Product name
- N-Boc-1-amino-cyclobutyl-methanol
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B603240
- Product name
- N-Boc-1-amino-cyclobutyl-methanol
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- B603240
- Product name
- N-Boc-1-amino-cyclobutyl-methanol
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 458247
- Product name
- N-Boc-1-amino-cyclobutyl-methanol
- Packaging
- 10mg
- Price
- $340
- Updated
- 2021/12/16
N-Boc-1-amino-cyclobutyl-methanol Chemical Properties,Usage,Production
Synthesis
163554-54-9
1142211-17-3
General procedure for the synthesis of tert-butyl (1-(hydroxymethyl)cyclobutyl)carbamate from ethyl BOC-1-aminocyclobutanecarboxylate: at -15 °C and under nitrogen protection, lithium aluminum hydride (12.8 mL, 25.6 mmol, 2.0 M THF solution) was added slowly and dropwise to a solution of ethyl 1-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate (2.97 g, 12.2 mmol) in ether (50 mL). mmol, 2.0 M THF solution), and the dropwise addition time was controlled to 40 min. The reaction mixture was maintained at -10 °C for 1.5 h. The reaction was then quenched sequentially with water (4 mL), 2N NaOH solution (5.4 mL) and additional water (11 mL). The reaction system was slowly warmed to room temperature and stirring was continued for 30 minutes. After drying by adding anhydrous magnesium sulfate, the filtrate was filtered through diatomaceous earth and the cake was washed well with ethyl acetate. The filtrate was concentrated to afford the target product, tert-butyl (1-(hydroxymethyl)cyclobutyl)carbamate, as an off-white solid (2.34 g, 95% yield).
References
[1] Patent: WO2016/179550, 2016, A1. Location in patent: Paragraph 0191
N-Boc-1-amino-cyclobutyl-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Boc-1-amino-cyclobutyl-methanol manufacturers
- Product
- tert-Butyl [1-(hydroxymethyl)cyclobutyl]carbamate 1142211-17-3
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18