ChemicalBook > CAS DataBase List > N-Boc-1-amino-cyclobutyl-methanol

N-Boc-1-amino-cyclobutyl-methanol

Product Name
N-Boc-1-amino-cyclobutyl-methanol
CAS No.
1142211-17-3
Chemical Name
N-Boc-1-amino-cyclobutyl-methanol
Synonyms
1-(Boc-amino)cyclobutylmethanol;N-Boc-1-amino-cyclobutyl-methanol;N-Boc-1-(hydroxyMethyl)cyclobutylaMine;Tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate;(1-hydroxyMethylcyclobutyl)carbaMic acid tert-butyl ester;tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate - [B16756];N-[1-(Hydroxymethyl)cyclobutyl]-carbamic acid tert-butyl ester;Carbamic acid, N-[1-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester
CBNumber
CB62502809
Molecular Formula
C10H19NO3
Formula Weight
201.26
MOL File
1142211-17-3.mol
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N-Boc-1-amino-cyclobutyl-methanol Property

Boiling point:
312.2±11.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.12±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C10H19NO3/c1-9(2,3)14-8(13)11-10(7-12)5-4-6-10/h12H,4-7H2,1-3H3,(H,11,13)
InChIKey
CLRGYDRXIYIAHC-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1(CO)CCC1
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Safety

HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B603240
Product name
N-Boc-1-amino-cyclobutyl-methanol
Packaging
50mg
Price
$55
Updated
2021/12/16
TRC
Product number
B603240
Product name
N-Boc-1-amino-cyclobutyl-methanol
Packaging
100mg
Price
$90
Updated
2021/12/16
TRC
Product number
B603240
Product name
N-Boc-1-amino-cyclobutyl-methanol
Packaging
250mg
Price
$175
Updated
2021/12/16
TRC
Product number
B603240
Product name
N-Boc-1-amino-cyclobutyl-methanol
Packaging
500mg
Price
$285
Updated
2021/12/16
Usbiological
Product number
458247
Product name
N-Boc-1-amino-cyclobutyl-methanol
Packaging
10mg
Price
$340
Updated
2021/12/16
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N-Boc-1-amino-cyclobutyl-methanol Chemical Properties,Usage,Production

Synthesis

163554-54-9

1142211-17-3

General procedure for the synthesis of tert-butyl (1-(hydroxymethyl)cyclobutyl)carbamate from ethyl BOC-1-aminocyclobutanecarboxylate: at -15 °C and under nitrogen protection, lithium aluminum hydride (12.8 mL, 25.6 mmol, 2.0 M THF solution) was added slowly and dropwise to a solution of ethyl 1-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate (2.97 g, 12.2 mmol) in ether (50 mL). mmol, 2.0 M THF solution), and the dropwise addition time was controlled to 40 min. The reaction mixture was maintained at -10 °C for 1.5 h. The reaction was then quenched sequentially with water (4 mL), 2N NaOH solution (5.4 mL) and additional water (11 mL). The reaction system was slowly warmed to room temperature and stirring was continued for 30 minutes. After drying by adding anhydrous magnesium sulfate, the filtrate was filtered through diatomaceous earth and the cake was washed well with ethyl acetate. The filtrate was concentrated to afford the target product, tert-butyl (1-(hydroxymethyl)cyclobutyl)carbamate, as an off-white solid (2.34 g, 95% yield).

References

[1] Patent: WO2016/179550, 2016, A1. Location in patent: Paragraph 0191

N-Boc-1-amino-cyclobutyl-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-1-amino-cyclobutyl-methanol Suppliers

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View Lastest Price from N-Boc-1-amino-cyclobutyl-methanol manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
tert-Butyl [1-(hydroxymethyl)cyclobutyl]carbamate 1142211-17-3
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18

1142211-17-3, N-Boc-1-amino-cyclobutyl-methanolRelated Search:

Ethylenediaminetetraacetic acid Benzamide, N-(1,1-dimethylethyl)-4-[[cis-5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-1'(2'H)-yl]sulfonyl]-3-methoxy-, (2E)-2-butenedioate (1:1) 2-(tert-Butylamino)ethyl methacrylate carbamic acid, n-[2-(5-pyrimidinyl, 2-chloro)ethyl]-, 1,1-dimethylethyl ester Carbamic acid, [1-(2-hydroxyethyl)cyclopropyl]-, 1,1-dimethylethyl ester (9CI) tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate (1-Aminomethyl-cyclobutyl)-carbamic acid tert-butyl ester

  • N-Boc-1-amino-cyclobutyl-methanol
  • (1-hydroxyMethylcyclobutyl)carbaMic acid tert-butyl ester
  • N-Boc-1-(hydroxyMethyl)cyclobutylaMine
  • Carbamic acid, N-[1-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester
  • Tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate
  • 1-(Boc-amino)cyclobutylmethanol
  • N-[1-(Hydroxymethyl)cyclobutyl]-carbamic acid tert-butyl ester
  • tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate - [B16756]
  • 1142211-17-3