tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate
- Product Name
- tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate
- CAS No.
- 107017-73-2
- Chemical Name
- tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate
- Synonyms
- tert-Butyl [1-(Hydroxymethyl)cyclopropyl]carbamate;tert-butyl N-[1-(hydroxymethyl)cyclopropyl]carbamate;SKL325;Boc-ACPC-ol;Boc-1-Aminocyclopropylmethanol;1-(Boc-amino)cyclopropylmethanol;Boc-1-aminocyclopropane methanol;N-Boc-1-AMinocyclopropylMethanol;1-Boc-Amino-cyclopropanemethanol;N-BOC-1-AMINO-CYCLOPROPANEMETHANOL
- CBNumber
- CB91508201
- Molecular Formula
- C9H17NO3
- Formula Weight
- 187.24
- MOL File
- 107017-73-2.mol
tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate Property
- Melting point:
- 81.0 to 85.0 °C
- Boiling point:
- 294.5±9.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 12.24±0.20(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C9H17NO3/c1-8(2,3)13-7(12)10-9(6-11)4-5-9/h11H,4-6H2,1-3H3,(H,10,12)
- InChIKey
- HFMAZNJKNNRONT-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1(CO)CC1
Safety
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B4251
- Product name
- [1-(tert-Butoxycarbonylamino)cyclopropyl]methanol
- Purity
- >97.0%(GC)
- Packaging
- 200mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- B4251
- Product name
- [1-(tert-Butoxycarbonylamino)cyclopropyl]methanol
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $132
- Updated
- 2024/03/01
- Product number
- B809783
- Product name
- tert-ButylN-[1-(Hydroxymethyl)cyclopropyl]carbamate
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR350017
- Product name
- Boc-1-Aminocyclopropylmethanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
- Product number
- CS-D0180
- Product name
- tert-butyl(1-(hydroxymethyl)cyclopropyl)carbamate
- Purity
- >98.0%
- Packaging
- 5g
- Price
- $78
- Updated
- 2021/12/16
tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate Chemical Properties,Usage,Production
Uses
Tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate could be converted into spirocyclopropanated analogues 14-CP and 14-CT of the insecticide Thiacloprid [1]. It can also be transformed into spirocyclopropanated analogs of Imidacloprid. This compound could be used to synthesize spirocyclopropanated five-membered ring analog 4-(3,5-Dichlorophenyl)-N-isopropyl-5-oxo-4,6-diazaspiro- [2.4]heptane-6-carboxamide[2].
Preparation
Tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate can be synthesized in three steps (40 % overall yield) from N, Ndibenzyl-2-benzyloxyacetamide starting with its reductive cyclopropanation (the de Meijere variant of the so-called Kulinkovich reaction). It can also be prepared in 56 % overall yield by monohydrolysis of commercially available diethyl cyclopropane-1,1-dicarboxylate followed by Curtius degradation of the carboxylic acid residue and subsequent reduction of the ester moiety[1].
References
[1] Brackmann F, et al. Synthesis of Spirocyclopropanated Analogues of Imidacloprid and Thiacloprid. European Journal of Organic Chemistry, 2005; 2005: 600-609.
[2] Brackmann F, et al. Synthesis of Spirocyclopropanated Analogues of Iprodione. European Journal of Organic Chemistry, 2005; 2005: 2250-2258.
tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate manufacturers
- Product
- Boc-1-Aminocyclopropylmethanol 107017-73-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- N-BOC-1-AMINO-CYCLOPROPANEMETHANOL 107017-73-2
- Price
- US $5.50/KG
- Min. Order
- 2KG
- Purity
- 96%-99%
- Supply Ability
- 100kg
- Release date
- 2019-09-04