ChemicalBook > CAS DataBase List > 4-(2-CHLOROACETYL)MORPHOLINE

4-(2-CHLOROACETYL)MORPHOLINE

Product Name
4-(2-CHLOROACETYL)MORPHOLINE
CAS No.
1440-61-5
Chemical Name
4-(2-CHLOROACETYL)MORPHOLINE
Synonyms
NSC 54542;BUTTPARK 30\04-53;AKOS BBS-00000944;TIMTEC-BB SBB005580;LABOTEST-BB LT00000129;N-(CHLOROACETYL)MORPHOLINE;4-(chloroacetyl)-morpholin;chloroaceticacidmorpholide;4-(CHLOROACETYL)MORPHOLINE;4-(2-CHLOROACETYL)MORPHOLINE
CBNumber
CB6250656
Molecular Formula
C6H10ClNO2
Formula Weight
163.6
MOL File
1440-61-5.mol
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4-(2-CHLOROACETYL)MORPHOLINE Property

Melting point:
26-30 °C
Boiling point:
152-160 °C(Press: 6 Torr)
Density 
1.257 g/mL at 25 °C
refractive index 
n20/D 1.512
Flash point:
110 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
-1.26±0.20(Predicted)
form 
Solid
color 
Colourless to Pale Yellow Oil
Stability:
Hygroscopic
CAS DataBase Reference
1440-61-5(CAS DataBase Reference)
EPA Substance Registry System
Morpholine, 4-(chloroacetyl)- (1440-61-5)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
RIDADR 
UN3261
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2588
Product name
2-Chloro-1-morpholinoethan-1-one
Purity
min. 98.0 %
Packaging
5G
Price
$54
Updated
2025/07/31
TCI Chemical
Product number
C2588
Product name
2-Chloro-1-morpholinoethan-1-one
Purity
min. 98.0 %
Packaging
25G
Price
$162
Updated
2025/07/31
TRC
Product number
C363700
Product name
4-(Chloroacetyl)morpholine
Packaging
10g
Price
$875
Updated
2021/12/16
Oakwood
Product number
005874
Product name
N-(Chloroacetyl)morpholine
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
Oakwood
Product number
005874
Product name
N-(Chloroacetyl)morpholine
Purity
98%
Packaging
5g
Price
$12
Updated
2021/12/16
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4-(2-CHLOROACETYL)MORPHOLINE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

The chloroacetyl derivatives are microbicides for adhesives, cellulose foams, oil emulsions, cooling water, etc.

Synthesis

110-91-8

79-04-9

1440-61-5

Step 1: Morpholine (1.00 mL, 11.5 mmol) and toluene (30 mL) were added to a dry three-necked flask equipped with a magnetic stirrer under nitrogen protection. Potassium carbonate (3.17 g, 22.9 mmol) was then added and stirred until completely dissolved. Chloroacetyl chloride (0.91 mL, 11.4 mmol) was slowly added dropwise under the cooling of an ice bath, and after completion of the dropwise addition, the ice bath was removed, the temperature was raised to 60 °C and the reaction was continuously stirred for 2 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, filtered to remove insoluble solids, and the solids were washed with a small amount of toluene. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent to give N-chloroacetylmorpholine as a white solid (1.87 g, quantitative yield). The product was characterized by 1H-NMR (270 MHz, CDCl3): δ 3.51-3.54 (m, 2H), 3.62-3.65 (m, 2H), 3.68-3.74 (m, 4H), 4.07 (s, 2H).

References

[1] Patent: EP1650194, 2006, A1. Location in patent: Page/Page column 34
[2] Patent: WO2012/72019, 2012, A1. Location in patent: Page/Page column 71-72
[3] Molecules, 2015, vol. 20, # 11, p. 19984 - 20013
[4] Patent: WO2016/147144, 2016, A1. Location in patent: Page/Page column 222
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6660 - 6671

4-(2-CHLOROACETYL)MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(2-CHLOROACETYL)MORPHOLINE manufacturers

Career Henan Chemical Co
Product
4-(2-CHLOROACETYL)MORPHOLINE 1440-61-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

1440-61-5, 4-(2-CHLOROACETYL)MORPHOLINERelated Search:

TIMTEC-BB SBB010861 4-(CHLOROACETYL)-2-METHYLMORPHOLINE 4-(2-chloropropanoyl)-2-methylmorpholine 4-(2-CHLOROACETYL)MORPHOLINE 4-[CHLORO(PHENYL)ACETYL]MORPHOLINE

  • 2-Chloro-1-(morpholin-4-yl)ethan-1-one
  • 4-(2-Chloroacetyl)morpholine 98%
  • 2-Chloro-1-morpholinoethan-1-one, 95+%
  • 2-CHLORO-1-MORPHOLIN-4-YL-ETHANONE >98%
  • 4-(CHLOROACETYL)MORPHOLINE, 97+%
  • 2-Chloro-1-(4-morpholinyl)ethanone, 2-Chloro-1-morpholinoethanone, 2-Morpholino-2-oxoethyl chloride, 4-Morpholinylcarbonylmethyl chloride, N-(Chloroacetyl)morpholine, Chloroacetic acid morpholide, Chloroacetic acid morpholine amide, Morpholine chloroacetamide
  • 1-Morpholino-2-chloroethanone
  • 2-Chloro-1-(4-Morpholinyl)ehanone
  • 2-Chloro-1-Morpholino-1-ethanone
  • 2-Chloro-1-Morpholinoethanone
  • 4-Morpholinylcarbonylmethyl chloride
  • Chloroacetic acid morpholine amide
  • NSC 54542
  • 2-Morpholino-2-oxoethyl chloride
  • MORPHOLINE, 4-(2-CHLOROACETYL)-
  • N-(CHLOROACETYL)MORPHOLINE
  • TIMTEC-BB SBB005580
  • 4-(chloroacetyl)-morpholin
  • chloroaceticacidmorpholide
  • LABOTEST-BB LT00000129
  • BUTTPARK 30\04-53
  • AKOS BBS-00000944
  • 4-(2-CHLOROACETYL)MORPHOLINE
  • 4-(CHLOROACETYL)MORPHOLINE
  • 2-CHLORO-1-MORPHOLIN-4-YL-ETHANONE
  • 2-CHLORO-1-MORPHOLINOETHAN-1-ONE
  • 2-CHLORO-1-(4-MORPHOLINYL)-1-ETHANONE
  • 4-(2-Chloroacetyl)morpholine, 97+%
  • Morpholine, 4-(chloroacetyl)- (6CI,7CI,8CI,9CI)
  • Ethanone, 2-chloro-1-(4-morpholinyl)-
  • 2-chloromorpholinoehtan-1-one
  • 2-Chloro-1-morpholin-4-yl-ethanon
  • TIANFU CHEM----4-(2-CHLOROACETYL)MORPHOLINE
  • 2-Chloro-1-(4-morpholinyl)ethanone
  • 1440-61-5
  • C6H10ClNO2
  • KETONE
  • ACETYLHALIDE
  • Heterocycles
  • MTS & Sulfhydryl Active Reagents