6-iodopyridazin-3-amine
- Product Name
- 6-iodopyridazin-3-amine
- CAS No.
- 187973-60-0
- Chemical Name
- 6-iodopyridazin-3-amine
- Synonyms
- 6-Iodo-3-pyridazinamine;3-Amino-6-iodopyridazine;3-Pyridazinamine, 6-iodo-;6-Iodopyridazin-3-amine, 3-Amino-6-iodo-1,2-diazine
- CBNumber
- CB62514093
- Molecular Formula
- C4H4IN3
- Formula Weight
- 221
- MOL File
- 187973-60-0.mol
6-iodopyridazin-3-amine Property
- Boiling point:
- 399.6±27.0 °C(Predicted)
- Density
- 2.204
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.24±0.10(Predicted)
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C4H4IN3/c5-3-1-2-4(6)8-7-3/h1-2H,(H2,6,8)
- InChIKey
- QHEUBRHRIJMZOR-UHFFFAOYSA-N
- SMILES
- C1(N)=NN=C(I)C=C1
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- 058078
- Product name
- 6-Iodopyridazin-3-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 058078
- Product name
- 6-Iodopyridazin-3-amine
- Purity
- 95%
- Packaging
- 5g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- 064949
- Product name
- 6-Iodopyridazin-3-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- X3258
- Product name
- 3-Amino-6-iodopyridazine
- Packaging
- 5g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 3H30-H-X1
- Product name
- 3-Amino-6-iodopyridazine
- Packaging
- 5G
- Price
- $250
- Updated
- 2021/12/16
6-iodopyridazin-3-amine Chemical Properties,Usage,Production
Synthesis
5469-69-2
187973-60-0
The general procedure for the synthesis of 6-iodopyridazin-3-amine from 3-amino-6-chloropyridazine was as follows: 6-chloropyridazin-3-amine (3.7 g, 28.56 mmol) was placed in a 100 mL round-bottomed flask fitted with a reflux condenser tube and a magnetic stirrer. Subsequently, hydrogen iodide (57 wt% aqueous solution, 20 mL, 265.96 mmol) was added to the flask, and the resulting dark brown solution was heated and stirred under mild reflux conditions for 6 hours. After completion of the reaction, the mixture was cooled to room temperature. The crude product was collected by filtration and the reaction vessel was washed with ice-cooled water (2 x 30 mL) and the washings were combined onto a filter cake. The resulting solid was partitioned between ethyl acetate and 2N aqueous sodium hydroxide solution. The organic layer was washed with aqueous sodium hydroxide, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 6-iodopyridazin-3-amine (4.10 g, 65% yield) as a solid. The product was characterized by 1H NMR (400 MHz, DMSO, 27 °C): δ 6.52 (2H, s), 6.55 (1H, d), 7.54 (1H, d).
References
[1] Patent: WO2013/178569, 2013, A1. Location in patent: Page/Page column 58-59
[2] Patent: US2015/87644, 2015, A1. Location in patent: Paragraph 0407-0409
[3] ACS Medicinal Chemistry Letters, 2010, vol. 1, # 2, p. 80 - 84
[4] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 243-244
[5] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 80 - 105
6-iodopyridazin-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-iodopyridazin-3-amine manufacturers
- Product
- 6-iodopyridazin-3-amine 187973-60-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09