N-Benzyl-3-pyrrolidinol
- Product Name
- N-Benzyl-3-pyrrolidinol
- CAS No.
- 775-15-5
- Chemical Name
- N-Benzyl-3-pyrrolidinol
- Synonyms
- idin-3-oL;N-benzyl-3-pyrrolitol;N-BENZYL-3-PYRROLIDINOL;1-BENZYL-3-PYRROLIDINOL;1-BENZYLPYRROLIDINE-3-OL;1-(benzyl)pyrrolidin-3-ol;1-Benzyl-3-pyrrolidinol >1-Benzyl-3-hydroxypyrrolidin;1-Phenylmethylpyrrolidin-3-ol;1-BENZYL-3-HYDROXYPYRROLIDINE
- CBNumber
- CB6251709
- Molecular Formula
- C11H15NO
- Formula Weight
- 177.24
- MOL File
- 775-15-5.mol
N-Benzyl-3-pyrrolidinol Property
- Boiling point:
- 113-115 °C2 mm Hg(lit.)
- Density
- 1.07 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.548(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 14.82±0.20(Predicted)
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- BRN
- 6039
- InChI
- InChI=1S/C11H15NO/c13-11-6-7-12(9-11)8-10-4-2-1-3-5-10/h1-5,11,13H,6-9H2
- InChIKey
- YQMXOIAIYXXXEE-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=CC=C2)CCC(O)C1
- CAS DataBase Reference
- 775-15-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 1
- F
- 10-34
- HazardClass
- 6.1
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 302821
- Product name
- 1-Benzyl-3-pyrrolidinol
- Purity
- 95%
- Packaging
- 5g
- Price
- $46.8
- Updated
- 2023/06/20
- Product number
- 302821
- Product name
- 1-Benzyl-3-pyrrolidinol
- Purity
- 95%
- Packaging
- 25g
- Price
- $73.5
- Updated
- 2023/06/20
- Product number
- B1597
- Product name
- 1-Benzyl-3-pyrrolidinol
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- B1597
- Product name
- 1-Benzyl-3-pyrrolidinol
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- U180
- Product name
- 1-Benzyl-3-pyrrolidinol
- Packaging
- 5g
- Price
- $71
- Updated
- 2021/12/16
N-Benzyl-3-pyrrolidinol Chemical Properties,Usage,Production
Uses
1-Benzyl-3-pyrrolidinol was used in preparation of:
- potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- (3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine
Synthesis Reference(s)
The Journal of Organic Chemistry, 51, p. 4296, 1986 DOI: 10.1021/jo00372a038
Synthesis
2419-74-1
100-46-9
775-15-5
The present embodiment is a method for the preparation of N-benzyl-3-hydroxypyrrolidine, which was carried out as follows: 250 g of 40 wt% aqueous benzylamine solution was added to a 500 mL four-necked flask and cooled to 10 °C. In an ice water bath, 102 g of 1,4-dichloro-2-butanol was added dropwise while stirring and the temperature was controlled at 15 °C. After the dropwise addition was completed in about 15 min, the system was transferred to a 500 mL autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1 MPa, and simultaneously heated to 120 ± 2 °C, and the reaction was stirred for about 10 h. The disappearance of the raw material was monitored by GC. At the end of the reaction, cooled to room temperature, the material was discharged, 110g of sodium hydroxide was added in batches, and the temperature was controlled to be lower than 50°C in order to release the methylamine gas and precipitate a large amount of white solids, stirring for 1h. After filtration, the filtrate was stratified, and the upper organic phase was treated with 100mL of ethanol and 18g of anhydrous magnesium sulphate, stirring for 2-3h. It was filtered again, and the filtrate was concentrated under vacuum to get a yellow transparent oily liquid, and finally By vacuum distillation, 46.7 g of colorless and transparent N-benzyl-3-hydroxypyrrolidine was obtained with 64.8% yield and 99.3% purity (HPLC).
References
[1] Patent: CN106631956, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027
N-Benzyl-3-pyrrolidinol Preparation Products And Raw materials
Raw materials
Preparation Products
N-Benzyl-3-pyrrolidinol Suppliers
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View Lastest Price from N-Benzyl-3-pyrrolidinol manufacturers
- Product
- N-Benzyl-3-pyrrolidinol 775-15-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-16
- Product
- 1-Benzyl-3-pyrrolidinol 775-15-5
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2021-11-12
- Product
- N-Benzyl-3-pyrrolidinol 775-15-5
- Price
- US $55.00/g
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-12-15