N-Benzyl-3-pyrrolidinol

Product Name: N-Benzyl-3-pyrrolidinol
CAS No.: 775-15-5
Chemical Name: N-Benzyl-3-pyrrolidinol
Synonyms: idin-3-oL;N-benzyl-3-pyrrolitol;N-BENZYL-3-PYRROLIDINOL;1-BENZYL-3-PYRROLIDINOL;1-BENZYLPYRROLIDINE-3-OL;1-(benzyl)pyrrolidin-3-ol;1-Benzyl-3-pyrrolidinol >1-Benzyl-3-hydroxypyrrolidin;1-Phenylmethylpyrrolidin-3-ol;1-BENZYL-3-HYDROXYPYRROLIDINE
CBNumber: CB6251709
Molecular Formula: C11H15NO
Formula Weight: 177.24
MOL File: 775-15-5.mol

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N-Benzyl-3-pyrrolidinol Property

Boiling point:: 113-115 °C2 mm Hg(lit.)
Density: 1.07 g/mL at 25 °C(lit.)
refractive index: n20/D 1.548(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.82±0.20(Predicted)
form: clear liquid
color: Colorless to Light yellow to Light orange
BRN: 6039
InChI: InChI=1S/C11H15NO/c13-11-6-7-12(9-11)8-10-4-2-1-3-5-10/h1-5,11,13H,6-9H2
InChIKey: YQMXOIAIYXXXEE-UHFFFAOYSA-N
SMILES: N1(CC2=CC=CC=C2)CCC(O)C1
CAS DataBase Reference: 775-15-5(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36/37/38
Safety Statements: 26-36
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 1
F: 10-34
HazardClass: 6.1
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 302821
Product name: 1-Benzyl-3-pyrrolidinol
Purity: 95%
Packaging: 5g
Price: $46.8
Updated: 2023/06/20

Sigma-Aldrich

Product number: 302821
Product name: 1-Benzyl-3-pyrrolidinol
Purity: 95%
Packaging: 25g
Price: $73.5
Updated: 2023/06/20

TCI Chemical

Product number: B1597
Product name: 1-Benzyl-3-pyrrolidinol
Purity: >96.0%(GC)
Packaging: 5g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: B1597
Product name: 1-Benzyl-3-pyrrolidinol
Purity: >96.0%(GC)
Packaging: 25g
Price: $70
Updated: 2025/07/31

AK Scientific

Product number: U180
Product name: 1-Benzyl-3-pyrrolidinol
Packaging: 5g
Price: $71
Updated: 2021/12/16

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N-Benzyl-3-pyrrolidinol Chemical Properties,Usage,Production

Uses

1-Benzyl-3-pyrrolidinol was used in preparation of:

potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
(3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 4296, 1986 DOI: 10.1021/jo00372a038

Synthesis

2419-74-1

100-46-9

775-15-5

The present embodiment is a method for the preparation of N-benzyl-3-hydroxypyrrolidine, which was carried out as follows: 250 g of 40 wt% aqueous benzylamine solution was added to a 500 mL four-necked flask and cooled to 10 °C. In an ice water bath, 102 g of 1,4-dichloro-2-butanol was added dropwise while stirring and the temperature was controlled at 15 °C. After the dropwise addition was completed in about 15 min, the system was transferred to a 500 mL autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1 MPa, and simultaneously heated to 120 ± 2 °C, and the reaction was stirred for about 10 h. The disappearance of the raw material was monitored by GC. At the end of the reaction, cooled to room temperature, the material was discharged, 110g of sodium hydroxide was added in batches, and the temperature was controlled to be lower than 50°C in order to release the methylamine gas and precipitate a large amount of white solids, stirring for 1h. After filtration, the filtrate was stratified, and the upper organic phase was treated with 100mL of ethanol and 18g of anhydrous magnesium sulphate, stirring for 2-3h. It was filtered again, and the filtrate was concentrated under vacuum to get a yellow transparent oily liquid, and finally By vacuum distillation, 46.7 g of colorless and transparent N-benzyl-3-hydroxypyrrolidine was obtained with 64.8% yield and 99.3% purity (HPLC).

References

[1] Patent: CN106631956, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027

N-Benzyl-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyl-3-pyrrolidinol Suppliers

Americas 1 Belgium 1 China 169 Europe 2 France 1 Germany 2 India 5 Japan 4 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 22 Global 218

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View Lastest Price from N-Benzyl-3-pyrrolidinol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Benzyl-3-pyrrolidinol 775-15-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-16

Shijiazhuang Gantuo Biotechnology Co., Ltd

Product: 1-Benzyl-3-pyrrolidinol 775-15-5
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2021-11-12

Qiuxian Baitai New Material Co., LTD

Product: N-Benzyl-3-pyrrolidinol 775-15-5
Price: US $55.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-12-15

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775-15-5

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