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QS11

Product Name
QS11
CAS No.
944328-88-5
Chemical Name
QS11
Synonyms
QS11;CS-346;BML-WN117;QS11 hydrate;QS11;BML-WN117;Wnt Synergist, QS11;QS11, ARFGAP1 inhibitor;Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem;(S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino);(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
CBNumber
CB62517933
Molecular Formula
C36H33N5O2
Formula Weight
567.69
MOL File
944328-88-5.mol
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QS11 Property

Boiling point:
852.2±75.0 °C(Predicted)
Density 
1.27
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble in DMSO
form 
Pale amber solid
pka
14.46±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681668
Product name
Wnt Synergist, QS11
Purity
A cell-permeable purine compound that binds ARFGAPs (
Packaging
5mg
Price
$575
Updated
2024/03/01
Cayman Chemical
Product number
21247
Product name
QS11
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21247
Product name
QS11
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21247
Product name
QS11
Purity
≥98%
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
21247
Product name
QS11
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
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QS11 Chemical Properties,Usage,Production

Description

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM. It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.

Uses

QS 11 is a small molecule Wnt synergistic agonist.

Definition

ChEBI: (2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol is a member of biphenyls.

in vitro

qs11 showed potent wnt synergist activity with little cytotoxicity in hek293 cells (ec50 = 0.5 μm) and human primary fibroblast cells (ec50 ≥ 10 μm). qs11 at 2.5 μm activated the super(8x)topflash reporter ~200-fold in the presence of wnt-3a conditioned medium. synergistic effect was also observed when qs11 was combined with recombinant wnt-3a protein (10–200 ng/ml) [2].

in vivo

in wnt signaling test model, embryos were injected with qs11, xwnt-8 rna or a combination of qs11and xwnt-8 rna. compared with qs11 alone and xwnt-8 rna alone, injection of a combination of xwnt-8 rna and qs11 induced significantly more full (20.9%) and partial (30.2%) double axis formation [2]..

storage

Store at +4°C

References

[1] singh mk1, gao h1, sun w1, song z1, schmalzigaug r2, premont rt2, zhang q3. structure-activity relationship studies of qs11, a small molecule wnt synergistic agonist. bioorg med chem lett. 2015 nov 1;25(21):4838-42.
[2] zhang q1, major mb, takanashi s, camp nd, nishiya n, peters ec, ginsberg mh, jian x, randazzo pa, schultz pg, moon rt, ding s. small-molecule synergist of the wnt/beta-catenin signaling pathway. proc natl acad sci u s a. 2007 may 1;104(18):7444-8. epub 2007 apr 25.

QS11 Preparation Products And Raw materials

Raw materials

Preparation Products

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QS11 Suppliers

China 58 China Hong Kong 1 United Kingdom 1 United States 18 Global 78
MedChemexpress LLC
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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InvivoChem
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+1-708-310-1919 +1-13798911105
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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United States
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2738
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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57505
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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38631
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United States Biological
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944328-88-5, QS11Related Search:


  • QS11
  • (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
  • (betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol
  • QS11 hydrate
  • Wnt Synergist, QS11
  • (S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)
  • QS 11 (betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol
  • (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
  • Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem
  • (S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol
  • CS-346
  • BML-WN117
  • QS11;BML-WN117
  • Benzenepropanol, β-[[9-([1,1'-biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]-, (βS)-
  • synergistic,Wnt,regenerative,agonist,signaling,factors,Inhibitor,QS11,inhibit,ADP-ribosylation,QS-11
  • (S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol
  • QS11, ARFGAP1 inhibitor
  • 944328-88-5
  • C36H33N5O2