ChemicalBook > CAS DataBase List > 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione

1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione

Product Name
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
CAS No.
376382-11-5
Chemical Name
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Synonyms
BRD 7389;BRD 7389 (BRD7389);BRD7389 >=98% (HPLC);Insulin Expression Inducer, BRD7389;1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-(Phenethylamino)-2H-naphtho[1,2,3-de]quinoline-2,7(3H)-dione;1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione;3H-Naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-phenylethyl)aMino]-;Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem
CBNumber
CB62518899
Molecular Formula
C24H18N2O2
Formula Weight
366.41
MOL File
376382-11-5.mol
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1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Property

Boiling point:
655.0±55.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
11.31±0.40(Predicted)
color 
orange
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B7563
Product name
BRD7389
Purity
≥98% (HPLC)
Packaging
5mg
Price
$177
Updated
2024/03/01
Sigma-Aldrich
Product number
203709
Product name
Insulin Expression Inducer, BRD7389
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
20214
Product name
BRD7389
Purity
≥95%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
20214
Product name
BRD7389
Purity
≥95%
Packaging
5mg
Price
$96
Updated
2024/03/01
Sigma-Aldrich
Product number
B7563
Product name
BRD7389
Purity
≥98% (HPLC)
Packaging
25mg
Price
$784
Updated
2022/05/15
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1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Chemical Properties,Usage,Production

Description

BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression. BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.

Definition

ChEBI: LSM-4550 is a member of anthracenes.

storage

Store at -20°C

References

1) Fomina-Yadlin et al. (2010), Small molecule inducers of insulin expression in pancreatic alpha-cells; Proc. Natl. Acad. Sci. USA, 107 15099 2) Choudhary et al. (2014), Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming; PLoS One, 9(4) e95194 3) Park and Cho (2012), EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-470 colon cancer cells by muscarinic acetylcholine receptors; Mol. Cell. Biochem., 370 191

1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Suppliers

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376382-11-5, 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dioneRelated Search:

BIO A 769662 Glibenclamide Andrographolide

  • BRD 7389
  • 3H-Naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-phenylethyl)aMino]-
  • 1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione
  • 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione
  • 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
  • Insulin Expression Inducer, BRD7389
  • BRD 7389 (BRD7389)
  • Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem
  • BRD7389 >=98% (HPLC)
  • BRD7389,cancer,S6K,Inhibitor,BRD 7389,colon,inhibit,RSK,islets,diabetes,BRD-7389,pancreatic,SNU-407,Ribosomal S6 Kinase (RSK)
  • 1-(Phenethylamino)-2H-naphtho[1,2,3-de]quinoline-2,7(3H)-dione
  • 376382-11-5