1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
- Product Name
- 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
- CAS No.
- 376382-11-5
- Chemical Name
- 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
- Synonyms
- BRD 7389;BRD 7389 (BRD7389);BRD7389 >=98% (HPLC);Insulin Expression Inducer, BRD7389;1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-(Phenethylamino)-2H-naphtho[1,2,3-de]quinoline-2,7(3H)-dione;1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione;3H-Naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-phenylethyl)aMino]-;Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem
- CBNumber
- CB62518899
- Molecular Formula
- C24H18N2O2
- Formula Weight
- 366.41
- MOL File
- 376382-11-5.mol
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Property
- Boiling point:
- 655.0±55.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- pka
- 11.31±0.40(Predicted)
- color
- orange
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B7563
- Product name
- BRD7389
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $177
- Updated
- 2024/03/01
- Product number
- 203709
- Product name
- Insulin Expression Inducer, BRD7389
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 20214
- Product name
- BRD7389
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 20214
- Product name
- BRD7389
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- B7563
- Product name
- BRD7389
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $784
- Updated
- 2022/05/15
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Chemical Properties,Usage,Production
Description
BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression. BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.
Definition
ChEBI: LSM-4550 is a member of anthracenes.
storage
Store at -20°C
References
1) Fomina-Yadlin et al. (2010), Small molecule inducers of insulin expression in pancreatic alpha-cells; Proc. Natl. Acad. Sci. USA, 107 15099 2) Choudhary et al. (2014), Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming; PLoS One, 9(4) e95194 3) Park and Cho (2012), EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-470 colon cancer cells by muscarinic acetylcholine receptors; Mol. Cell. Biochem., 370 191