ChemicalBook > CAS DataBase List > 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

Product Name
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
CAS No.
511296-88-1
Chemical Name
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
Synonyms
PFT-β;CS-1771;HY-16702A;Pifithrin B;Pifithrin-β;Cyclic PFT-α;Cyclic PFT-α;Pifithrin-beta;Cyclic Pifithrin-α;Pifithrin-β(PPT-β)
CBNumber
CB62518925
Molecular Formula
C16H16N2S.HBr
Formula Weight
349
MOL File
511296-88-1.mol
More
Less

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Property

storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL
form 
powder to crystal
color 
White to Almost white
Merck 
14,7421
More
Less

Safety

WGK Germany 
3
HS Code 
2934.99.4400
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P4236
Product name
Cyclic Pifithrin-α hydrobromide
Purity
≥98% (HPLC)
Packaging
5mg
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
P4236
Product name
Cyclic Pifithrin-α hydrobromide
Purity
≥98% (HPLC)
Packaging
10mg
Price
$336
Updated
2024/03/01
TCI Chemical
Product number
C2826
Product name
Cyclic Pifithrin-alpha Hydrobromide
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$336
Updated
2023/01/07
TCI Chemical
Product number
C2826
Product name
Cyclic Pifithrin-alpha Hydrobromide
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$805
Updated
2024/03/01
Cayman Chemical
Product number
14748
Product name
Cyclic Pifithrin-α (hydrobromide)
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
More
Less

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Chemical Properties,Usage,Production

Description

Pifithrin-α (PFT-α; ) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively). At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents. In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.

Uses

Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke?induced apoptosis of pulmonary endothelial cells.

Biochem/physiol Actions

A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.

in vitro

pifithrin-α blocks p53-dependent transactivation of p53-responsive genes in cona cells. pifithrin-α (10 μm) inhibits apoptotic death of c8 cells guided by etoposide, taxol, dox, cytosine arabinoside. pifithrin-α has significant effect on the inhibition of p53-dependent growth arrest of human diploid fibroblasts in response to dna damage but not on p53-deficient fibroblasts. pifithrin-α may monitor the nuclear import or export (or both) of p53 or may make nuclear p53 instability [2].

in vivo

pifithrin-α-mice (2.2 mg/kg i.p.) were completely survival with both strains from 60% killing doses of gamma irradiation (8 gy for c57bl and 6 gy for balb/c). mice pretreated with pfithrin-α lost less weight than irradiated mice without the pifithrin-α. pifithrin-α (2.2 mg/kg) eliminates p53-dependent regulation of dna replication after whole-body gamma irradiation in mice [2].

storage

Desiccate at RT

References

[1] komarova ea and gudkov a v. could p53 be a target for therapeutic suppression semin. cancer biol. 1998, 8: 389-400.
[2] komarov pg, komarova ea, kondratov rv, christov-tselkov k, coon js, chernov mv, gudkov av. a chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. science. 1999 sep 10; 285(5434):1733-7.

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Suppliers

Americas 1 China 70 Europe 1 India 3 Japan 1 United Kingdom 1 United States 15 Global 92
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
More
Less

View Lastest Price from 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide manufacturers

Career Henan Chemical Co
Product
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide 511296-88-1
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

511296-88-1, 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromideRelated Search:

2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Citalopram hydrobromide Ascorbic Acid

  • 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
  • Cyclic Pifithrin-α HBr
  • Pifithrin- beta hydrobromide
  • Cyclic PFT-α
  • Pifithrin B
  • PIFITHRIN-Β;PIFITHRIN B;CYCLIC PFT-Α; PIFITHRIN-Β; PFT-Β
  • CS-1771
  • CYCLIC PIFITHRIN-Α HYDROBROMIDE;CYCLIC PFT-Α HYDROBROMIDE;PFT-Β HYDROBROMIDE
  • Cyclic Pifithrin-α hydrobromide
  • Pifithrin-beta
  • Cyclic Pifithrin-alpha HydrobroMide
  • 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Pifithrin-β
  • 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide
  • Cyclic PFT-α hydrobromide
  • Pifithrin-α, cyclic
  • HY-16702A
  • Cyclic Pifithrin-α Hydrobromide &gt
  • Pifithrin-β
  • Pifithrin-β hydrobromide
  • Cyclic Pifithrin-α
  • 2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide
  • Pifithrin-α, Cyclic, hydrobromide
  • Pifithrin-β HBr (QB102
  • Cyclic Pifithrin-α Hydrobromide
  • Cyclic PFT-α
  • PFT β (hydrobromide)
  • PFT-β
  • 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole hydrobromide
  • Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)
  • 5,6,7,8-tetrahydro-2-(4-methylphenyl)-Imidazo[2,1-b]benzothiazole hydrobromide (1:1)
  • inhibit,MDM-2/p53,Pifithrinβ hydrobromide,Ferroptosis,Pifithrin β hydrobromide,Cyclic Pifithrin-α,Inhibitor,PFT β
  • Pifithrin-β(PPT-β)
  • 511296-88-1
  • C16H16N2SHBr
  • C16H16N2SBrH