ChemicalBook > CAS DataBase List > 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

Product Name
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
CAS No.
883031-03-6
Chemical Name
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Synonyms
HC 067047;HC-067047 (HC067047;HC-067047 >=98% (HPLC);HC-067047, 10 mM in DMSO;HC 067047, TRPV4 antagonist;TRPV4 Antagonist II, HC-067047;Transient receptor potential channels,HC-067047,Inhibitor,HC 067047,TRP Channel,inhibit;2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide;2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide;1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-
CBNumber
CB62518965
Molecular Formula
C26H28F3N3O2
Formula Weight
471.51
MOL File
883031-03-6.mol
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2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Property

storage temp. 
2-8°C
solubility 
DMSO: ≥15mg/mL
form 
powder
color 
white to tan
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
NCZYSQOTAYFTNM-UHFFFAOYSA-N
SMILES
CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0143
Product name
HC-067047
Purity
≥98% (HPLC)
Packaging
5mg
Price
$111.15
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0143
Product name
HC-067047
Purity
≥98% (HPLC)
Packaging
25mg
Price
$472
Updated
2025/07/31
Sigma-Aldrich
Product number
616521
Product name
TRPV4 Antagonist II, HC-067047
Purity
The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.
Packaging
10 mg
Price
$159
Updated
2025/07/31
Cayman Chemical
Product number
20927
Product name
HC-067047
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20927
Product name
HC-067047
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
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2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Chemical Properties,Usage,Production

Description

HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 blocker. Active at mouse, human and rat TRPV4, IC50= 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.1 Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis.1 Inhibits brain edema in middle cerebral artery occlusion mice.2 HC-067047 induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats.3Activein vivo.

Uses

HC-067047has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4)inhibitor:

  • to study its effects on organoid formation and proliferation in human endometrial tissues
  • to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)
  • to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus

Biochem/physiol Actions

HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC50 values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC50 values of 370 and 780 nM, respectively.

in vivo

HC-067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes; cyclophosphamide-treated WT and Trpv4 / mice, and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis. HC-067047 do not affect bladder function in Trpv4 / mice[1].

Animal Model:Cyclophosphamide-treated WT and Trpv4/ mice, and naive WT mice[1]
Dosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg
Administration:Intraperitoneal injection; for 30 minutes
Result:Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4/ mice.

storage

+4°C

References

[1] WOUTER EVERAERTS. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 19084-19089. DOI:10.1073/pnas.1005333107
[2] PINGHUI JIE. Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice.[J]. Frontiers in Cellular Neuroscience, 2015: 141. DOI:10.3389/fncel.2015.00141
[3] R. C. L. VIZIN. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats[J]. Acta Physiologica, 2015, 214 2: 275-289. DOI:10.1111/apha.12477

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Suppliers

China 85 United Kingdom 1 United States 14 USA 1 Global 101
3B Pharmachem (Wuhan) International Co.,Ltd.
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021-18621020637 18621020637
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Shanghai Macklin Biochemical Co.,Ltd.
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883031-03-6, 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamideRelated Search:

Minoxidil 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-

  • 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
  • HC 067047
  • 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
  • 1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-
  • HC-067047 >=98% (HPLC)
  • Transient receptor potential channels,HC-067047,Inhibitor,HC 067047,TRP Channel,inhibit
  • HC 067047, TRPV4 antagonist
  • HC-067047, 10 mM in DMSO
  • TRPV4 Antagonist II, HC-067047
  • HC-067047 (HC067047
  • 883031-03-6
  • C26H28F3N3O2
  • Potent and selective TRPV4 antagonist.