ChemicalBook > CAS DataBase List > PF-04457845

PF-04457845

Product Name
PF-04457845
CAS No.
1020315-31-4
Chemical Name
PF-04457845
Synonyms
CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
CBNumber
CB62522724
Molecular Formula
C23H20F3N5O2
Formula Weight
455.43
MOL File
1020315-31-4.mol
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PF-04457845 Property

Boiling point:
687.0±55.0 °C(Predicted)
Density 
1.389±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form 
powder
pka
12.72±0.20(Predicted)
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0184
Product name
PF-04457845
Purity
≥98% (HPLC)
Packaging
5MG
Price
$108
Updated
2023/06/20
Sigma-Aldrich
Product number
PZ0184
Product name
PF-04457845
Purity
≥98% (HPLC)
Packaging
25MG
Price
$438
Updated
2023/06/20
Cayman Chemical
Product number
19306
Product name
PF-04457845
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
19306
Product name
PF-04457845
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19306
Product name
PF-04457845
Purity
≥98%
Packaging
25mg
Price
$286
Updated
2024/03/01
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PF-04457845 Chemical Properties,Usage,Production

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

storage

Store at +4°C

PF-04457845 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-04457845 Suppliers

Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1020315-31-4, PF-04457845Related Search:


  • N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
  • PF-04457845
  • N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide
  • PF-04457845;PF04457845
  • 1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
  • N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide
  • CS-1549
  • PF-04457845 >=98% (HPLC)
  • Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor
  • 1020315-31-4
  • C23H20F3N5O2