ChemicalBook > CAS DataBase List > PF-04457845
PF-04457845
- Product Name
- PF-04457845
- CAS No.
- 1020315-31-4
- Chemical Name
- PF-04457845
- Synonyms
- CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
- CBNumber
- CB62522724
- Molecular Formula
- C23H20F3N5O2
- Formula Weight
- 455.43
- MOL File
- 1020315-31-4.mol
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PF-04457845 Property
- Boiling point:
- 687.0±55.0 °C(Predicted)
- Density
- 1.389±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
- form
- powder
- pka
- 12.72±0.20(Predicted)
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PZ0184
- Product name
- PF-04457845
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $108
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- PZ0184
- Product name
- PF-04457845
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $438
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 19306
- Product name
- PF-04457845
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19306
- Product name
- PF-04457845
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19306
- Product name
- PF-04457845
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $286
- Updated
- 2024/03/01
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PF-04457845 Chemical Properties,Usage,Production
Biochem/physiol Actions
PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.
storage
Store at +4°C
PF-04457845 Preparation Products And Raw materials
Raw materials
Preparation Products
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