1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
- Product Name
- 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
- CAS No.
- 116119-01-8
- Chemical Name
- 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
- Synonyms
- Methyl 3,4-Methylenedioxy-5-hydroxybenzoate;methyl 7-hydroxy-1,3-benzodioxole-5-carboxylate;methyl 7-hydroxy-2H-1,3-benzodioxole-5-carboxylate;Methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate;7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester;1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester;7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester, CAS 116119-01-8
- CBNumber
- CB62522890
- Molecular Formula
- C9H8O5
- Formula Weight
- 196.16
- MOL File
- 116119-01-8.mol
1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- CDCl3, DCM, Ethanol, Ethyl Acetate,
- form
- Solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H808470
- Product name
- 7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster
- Packaging
- 1g
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- 58658
- Product name
- 7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster
- Packaging
- 100mg
- Price
- $625
- Updated
- 2021/12/16
- Product number
- 58658
- Product name
- 7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster
- Packaging
- 1g
- Price
- $2000
- Updated
- 2021/12/16
- Product number
- CD11343437
- Product name
- Methyl7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $94
- Updated
- 2021/12/16
- Product number
- CD11343437
- Product name
- Methyl7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $151
- Updated
- 2021/12/16
1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Chemical Properties,Usage,Production
Uses
7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester is an intermediate in the synthesis of natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines.
Synthesis
75-11-6
99-24-1
116119-01-8
Potassium carbonate (4.002 g, 29 mmol) and methyl gallate (6 g, 29.7 mmol) were dissolved in anhydrous dichloromethane followed by the addition of diiodomethane (2.8 mL, 34.8 mmol) under nitrogen atmosphere and at room temperature. The reaction mixture was stirred at 0 °C for 5 h and then warmed up to 120 °C to continue the reaction. Upon completion of the reaction, the mixture was poured into cooled water (500 mL) and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 15% ethyl acetate/hexane) to afford the target product methyl 7-hydroxybenzo[d][1,3]meso-dioxole-5-carboxylate (3.6 g, 58% yield) as a white amorphous powder.
References
[1] Tetrahedron Asymmetry, 2009, vol. 20, # 4, p. 440 - 448
[2] Synlett, 2018, vol. 29, # 7, p. 908 - 911
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2297 - 2298
[4] Liebigs Annalen der Chemie, 1994, # 4, p. 361 - 364
[5] Synthesis, 2009, # 20, p. 3383 - 3390
1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 15026594951
- Fax
- 0556-5030632
- rs@raise-chem.com
- Country
- China
- ProdList
- 4454
- Advantage
- 55
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 13391076197
- tombiopharma@163.com
- Country
- China
- ProdList
- 4987
- Advantage
- 55
- Tel
- 13564638271
- Fax
- 021-68948280
- shhjiang1977@163.com
- Country
- China
- ProdList
- 2987
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12475
- Advantage
- 58