ChemicalBook > CAS DataBase List > (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
(3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
- Product Name
- (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
- CAS No.
- 625471-04-7
- Chemical Name
- (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
- Synonyms
- (S)-tert-butyl 3-aMinoazepane-1-carboxylate;tert-butyl (3S)-3-aMinoazepane-1-carboxylate;3615-A3;Diltiazem Impurity 22;(S)-3-AMINO-1-BOC-AZEPANE;tert-Butyl-3-aminoazepan-1-carboxylat;tert-Butyl (3S)-3-Aminoazepan-1-carboxylic;tert-butyl(S)-3-aminoazepane-1-carboxylate;(3S)-Amino-azepane-1-carboxylic acid tert-butyl ester;(3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
- CBNumber
- CB62548676
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 625471-04-7.mol
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(3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester Property
- Boiling point:
- 296.5±33.0 °C(Predicted)
- Density
- 1.020
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.35±0.20(Predicted)
- form
- liquid
- color
- Yellow to brown
- optical activity
- Consistent with structure
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A583805
- Product name
- (3S)-3-Aminoazepane-1-carboxylicAcidtert-ButylEster
- Packaging
- 50mg
- Price
- $165
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H51-1-2Y
- Product name
- tert-Butyl (3S)-3-aminoazepane-1-carboxylate
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR918689
- Product name
- (S)-tert-Butyl3-aminoazepane-1-carboxylate
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9430AB
- Product name
- (S)-tert-Butyl3-aminoazepane-1-carboxylate
- Packaging
- 1g
- Price
- $332
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR918689
- Product name
- (S)-tert-Butyl3-aminoazepane-1-carboxylate
- Packaging
- 1g
- Price
- $167
- Updated
- 2021/12/16
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(3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester Chemical Properties,Usage,Production
Uses
(3S)-3-Aminoazepane-1-carboxylic Acid tert-Butyl Ester is used in the preparation of ureidothiophenes, as CHK1 kinase inhibitors for treating neoplasm.
Synthesis
13139-12-3
107885-67-6
625471-04-7
The general procedure for the synthesis of tert-butyl (S)-3-aminoazepane-1-carboxylate from tert-butyl N-succinimidocarbonate and (S)-azepan-3-amine was as follows: (S)-azepan-3-ylamine (5 g, 43.8 mmol) was dissolved in 100 mL of anhydrous dichloromethane and cooled to -78 °C with magnetic stirring. In another flask, N-tert-butoxycarbonyloxy sulfonamidine (Boc-OSu, 9.7 g, 45 mmol) was dissolved in 50 mL of anhydrous dichloromethane. The succinimide solution was slowly added to the stirring amine solution over 10-15 minutes, keeping the reaction mixture at -78 °C. After addition, the reaction mixture was allowed to gradually warm to room temperature and stirring was continued for 4 hours or the completion of the reaction was confirmed by thin layer chromatography (TLC, ninhydrin color development; Rf 0.3; unfolding reagent ratio of 0.1:1:10 ammonia, methanol and dichloromethane). The reaction mixture was washed with 50 mL of water, and the aqueous layer was adjusted to pH >13 by addition of 6N sodium hydroxide and subsequently extracted with dichloromethane (3 × 100 mL). The organic layer was dried over anhydrous sodium carbonate, filtered and concentrated in vacuum to give pure tert-butyl (S)-3-aminoazepane-1-carboxylate as a viscous oil (5.1 g, 54% yield).
References
[1] Patent: WO2005/16909, 2005, A1. Location in patent: Page/Page column 68
[2] Patent: WO2005/66163, 2005, A2. Location in patent: Page/Page column 55-26
(3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester manufacturers
Career Henan Chemical Co
- Product
- (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester 25471-04-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100 kg
- Release date
- 2020-01-10
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