(5-BroMothiazol-2-yl)Methanol

(5-BroMothiazol-2-yl)Methanol Property

Boiling point:

277.6±20.0 °C(Predicted)

Density 

1.899±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

12.74±0.10(Predicted)

Appearance

White to off-white Solid

Safety

HS Code 

2934208090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

(5-BroMothiazol-2-yl)Methanol Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 2-(hydroxymethyl)-5-bromothiazole using 5-bromothiazole-2-carboxaldehyde as starting material: a methanol (1.00 mL) solution of 5-bromothiazole-2-carboxaldehyde (0.100 g, 0.521 mmol) was slowly added dropwise to a methanol (2.0 mL) solution of sodium borohydride (0.030 g, 0.781 mmol) under stirring conditions. After the dropwise addition, the reaction mixture was allowed to stand at room temperature for 5 minutes, followed by continued stirring for 1 hour. Upon completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was dissolved and partitioned between ethyl acetate and water. After separation of the organic layer, the aqueous phase was further extracted with ethyl acetate. All organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 2-(hydroxymethyl)-5-bromothiazole (0.067 g, 66% yield) as a dark-colored oil.LCMS analysis showed the [M + H]+ peak at 195.9.

References

[1] Patent: WO2012/149236, 2012, A1. Location in patent: Page/Page column 136
[2] Patent: WO2004/46101, 2004, A2. Location in patent: Page 31-32