ChemicalBook > CAS DataBase List > TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

Product Name: TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
CAS No.: 216064-48-1
Chemical Name: TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
Synonyms: 2-Boc-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;N-BOC-1,2,3,4-tetrahydro-5-hydeoxy-isoquinoline;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLAT;tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;Tert-Butyl 5-hydroxy-3,4-dihydro-2(1H)-iso quinoline carboxylate;2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+%;5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester
CBNumber: CB6258733
Molecular Formula: C14H19NO3
Formula Weight: 249.31
MOL File: 216064-48-1.mol

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Property

Boiling point:: 378.6±42.0 °C(Predicted)
Density: 1.170±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.96±0.20(Predicted)
Appearance: Off-white to light brown Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933491090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 066676
Product name: tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
Packaging: 1g
Price: $289
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-378
Product name: tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
Packaging: 1g
Price: $303
Updated: 2021/12/16

AK Scientific

Product number: 0992AB
Product name: tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
Packaging: 500mg
Price: $337
Updated: 2021/12/16

Apolloscientific

Product number: OR318035
Product name: tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 95+%
Packaging: 1g
Price: $441
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0166476
Product name: TERT-BUTYL-5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
Purity: 97.00%
Packaging: 1G
Price: $748.44
Updated: 2021/12/16

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

24424-99-5

2439-04-5

216064-48-1

(1) Platinum oxide (100 mg) was added to a solution of 5-hydroxyisoquinoline (2.9 g, 20 mmol) in acetic acid (30 mL) and the hydrogenation reaction was carried out at room temperature and atmospheric pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was crystallized by toluene (20 mL) and collected by filtration. The resulting crystals were dissolved in a solvent mixture of 1 N aqueous sodium hydroxide (40 mL) and tetrahydrofuran (40 mL), followed by addition of di-tert-butyl dicarbonate (4.8 g, 22 mmol). The reaction mixture was stirred at room temperature for 1 h, after which 1 N hydrochloric acid (40 mL) was added. Extraction was carried out with ether, the extract was dried over anhydrous magnesium sulfate and the solvent was removed by evaporation under reduced pressure. The precipitated crystals were recrystallized by diisopropyl ether to give colorless crystals of 2-tert-butoxycarbonyl-5-hydroxy-tetrahydroisoquinoline (2.9 g, 58% yield). Melting point: 163-164 °C. 1H-NMR (CDCl3) δ: 1.49 (9H, s), 2.76 (2H, t, J = 6.0 Hz).

References

[1] Patent: EP1123918, 2001, A1
[2] Patent: WO2016/108045, 2016, A2. Location in patent: Page/Page column 29

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Suppliers

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View Lastest Price from TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 216064-48-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-02

216064-48-1, TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATERelated Search:

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

N-BOC-1,2,3,4-tetrahydro-5-hydeoxy-isoquinoline

5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+%

tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLAT

2-Boc-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Tert-Butyl 5-hydroxy-3,4-dihydro-2(1H)-iso quinoline carboxylate

216064-48-1