TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
- Product Name
- TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
- CAS No.
- 216064-48-1
- Chemical Name
- TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
- Synonyms
- 2-Boc-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;N-BOC-1,2,3,4-tetrahydro-5-hydeoxy-isoquinoline;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLAT;tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;Tert-Butyl 5-hydroxy-3,4-dihydro-2(1H)-iso quinoline carboxylate;2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+%;5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester
- CBNumber
- CB6258733
- Molecular Formula
- C14H19NO3
- Formula Weight
- 249.31
- MOL File
- 216064-48-1.mol
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Property
- Boiling point:
- 378.6±42.0 °C(Predicted)
- Density
- 1.170±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.96±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 066676
- Product name
- tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Packaging
- 1g
- Price
- $289
- Updated
- 2021/12/16
- Product number
- 4H56-1-378
- Product name
- tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Packaging
- 1g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- 0992AB
- Product name
- tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Packaging
- 500mg
- Price
- $337
- Updated
- 2021/12/16
- Product number
- OR318035
- Product name
- tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $441
- Updated
- 2021/12/16
- Product number
- CHM0166476
- Product name
- TERT-BUTYL-5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $748.44
- Updated
- 2021/12/16
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
24424-99-5
2439-04-5
216064-48-1
(1) Platinum oxide (100 mg) was added to a solution of 5-hydroxyisoquinoline (2.9 g, 20 mmol) in acetic acid (30 mL) and the hydrogenation reaction was carried out at room temperature and atmospheric pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was crystallized by toluene (20 mL) and collected by filtration. The resulting crystals were dissolved in a solvent mixture of 1 N aqueous sodium hydroxide (40 mL) and tetrahydrofuran (40 mL), followed by addition of di-tert-butyl dicarbonate (4.8 g, 22 mmol). The reaction mixture was stirred at room temperature for 1 h, after which 1 N hydrochloric acid (40 mL) was added. Extraction was carried out with ether, the extract was dried over anhydrous magnesium sulfate and the solvent was removed by evaporation under reduced pressure. The precipitated crystals were recrystallized by diisopropyl ether to give colorless crystals of 2-tert-butoxycarbonyl-5-hydroxy-tetrahydroisoquinoline (2.9 g, 58% yield). Melting point: 163-164 °C. 1H-NMR (CDCl3) δ: 1.49 (9H, s), 2.76 (2H, t, J = 6.0 Hz).
References
[1] Patent: EP1123918, 2001, A1
[2] Patent: WO2016/108045, 2016, A2. Location in patent: Page/Page column 29
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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- Product
- TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 216064-48-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02