ChemicalBook > CAS DataBase List > 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
- Product Name
- 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
- CAS No.
- 442666-98-0
- Chemical Name
- 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
- Synonyms
- Anguizole;7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-
- CBNumber
- CB62589615
- Molecular Formula
- C17H11ClF2N4O2S
- Formula Weight
- 408.81
- MOL File
- 442666-98-0.mol
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7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Property
- Density
- 1.59
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 9.14±0.46(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0558
- Product name
- Anguizole
- Purity
- 99.48%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3182
- Product name
- Anguizole
- Packaging
- 5mg
- Price
- $159
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0558
- Product name
- Anguizole
- Purity
- 99.48%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3182
- Product name
- Anguizole
- Packaging
- 10mg
- Price
- $264
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0001852
- Product name
- ANGUIZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $279.4
- Updated
- 2021/12/16
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7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical Properties,Usage,Production
Biological Activity
anguizole is a selective inhibitor of ns4b with ic50 value of 310 nm [1].ns4b (nonstructural protein 4b) is a viral protein which was found in hepatitis c virus and was a key regulator in hcv replication complex formation. it is reported that ns4b plays a pivotal role in hcv replication via inducing a specific membrane rearrangement and designating membranous web. ns4b-ah2, comprising amino acid 42 to 66, is identified as a major regulator for ns4b oligomerization [2].anguizole is a potent ns4b inhibitor and targets the second amphipathic helix of ns4b (ns4b-ah2). when tested with hcv virus, anguizole treatment significantly disrupted ns4b-ah2-mediated biological functions of ns4b which played an important role in hcv life cycle [3]. in huh7.5 cells transferring a plasmid expressing ns4b fused in frame with gfp, 5μm anguizole treatment (48 hours) altered the distribution of ns4b maf pattern which inhibited hcv life cycle [1].
target
HCV
References
[1]. bryson, p.d., et al., a small molecule inhibits hcv replication and alters ns4b's subcellular distribution. antiviral res, 2010. 87(1): p. 1-8.
[2]. gouttenoire, j., et al., aminoterminal amphipathic alpha-helix ah1 of hepatitis c virus nonstructural protein 4b possesses a dual role in rna replication and virus production. plos pathog, 2014. 10(10): p. e1004501.
[3]. choi, m., et al., a hepatitis c virus ns4b inhibitor suppresses viral genome replication by disrupting ns4b's dimerization/multimerization as well as its interaction with ns5a. virus genes, 2013. 47(3): p. 395-407.
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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