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3-bromo-5-phenyl Salicylic Acid

Product Name
3-bromo-5-phenyl Salicylic Acid
CAS No.
4906-68-7
Chemical Name
3-bromo-5-phenyl Salicylic Acid
Synonyms
NSC-109116;AKR1C1-IN-1;XVZSXNULHSIRCQ-UHFFFAOYSA-N;3-bromo-5-phenylsalicyclic acid;3-bromo-5-phenyl Salicylic Acid;3-bromo-5-phenyl Salicylic Acid Exclusive;5-Bromo-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-;inhibit,AKR-1C1-IN-1,progesterone,AKR1C1IN1,AKR1C1 IN 1,Inhibitor,AKR1C1
CBNumber
CB62590019
Molecular Formula
C13H9BrO3
Formula Weight
293.11
MOL File
4906-68-7.mol
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3-bromo-5-phenyl Salicylic Acid Property

Melting point:
212-214 °C
Boiling point:
401.2±45.0 °C(Predicted)
Density 
1.611±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 0.1 mg/ml
form 
A crystalline solid
pka
2.45±0.14(Predicted)
color 
White to pink
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
123850
Product name
AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem
Purity
The AKR1C1 Inhibitor, 5-PBSA, also referenced under CAS 4906-68-7, controls the biological activity of AKR1C1.
Packaging
25MG
Price
$272
Updated
2024/03/01
Cayman Chemical
Product number
13574
Product name
3-bromo-5-phenyl Salicylic Acid
Purity
≥95%
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
13574
Product name
3-bromo-5-phenyl Salicylic Acid
Purity
≥95%
Packaging
5mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
13574
Product name
3-bromo-5-phenyl Salicylic Acid
Purity
≥95%
Packaging
10mg
Price
$497
Updated
2024/03/01
Cayman Chemical
Product number
13574
Product name
3-bromo-5-phenyl Salicylic Acid
Purity
≥95%
Packaging
25mg
Price
$1084
Updated
2024/03/01
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3-bromo-5-phenyl Salicylic Acid Chemical Properties,Usage,Production

Description

The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).

3-bromo-5-phenyl Salicylic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-bromo-5-phenyl Salicylic Acid Suppliers

China 23 United States 7 Global 30
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View Lastest Price from 3-bromo-5-phenyl Salicylic Acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-bromo-5-phenyl Salicylic Acid 4906-68-7
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-09

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